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Biocompatible coating, method, and use of medical surfaces

A polymer layer and substance technology, applied in coatings, drug combinations, antipyretics, etc., can solve the problems of difficult determination of active agent content, enlarged area, uniform dispersion of fluid oil, etc.

Inactive Publication Date: 2007-03-07
HEMOTEQ AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it should also be considered that it is indeed difficult to evenly disperse the fluid oil on the stent and that the stent remains uncoated to some extent
In addition, the stent loses other coating material on its way to the end point, making the uncoated area larger, and the amount of active agent that can actually be used at the target is ultimately extremely difficult to determine

Method used

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  • Biocompatible coating, method, and use of medical surfaces
  • Biocompatible coating, method, and use of medical surfaces
  • Biocompatible coating, method, and use of medical surfaces

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0102] Polymerization of 100% Linseed Oil at 80°C

[0103] Linseed oil was deposited as a thin film on the slides and then stored in a dry oven at 80°C. Polymerization was complete after two days. A homogeneous light yellow dry polymer layer is obtained which is well adhered to the surface.

example 2

[0105] Polymerization of 100% linseed oil at room temperature

[0106] Linseed oil was deposited as a thin film on slides and stored under air and exposed to UV radiation (light). Polymerization was complete after 14 days and the oil had solidified.

example 3

[0108] Polymerization of a mixture of linseed oil and olive oil (4:1)

[0109] A mixture of 80% linseed oil and 20% olive oil was prepared and deposited as a film on slides and stored in a dry oven at 80°C. Although the oil became solid after 2 days, it was still characterized by a sticky surface. In the presence of higher amounts of olive oil, a liquid consistency remains.

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PUM

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Abstract

The invention relates to a medical product having a surface at least partially covered by a polymer layer. The polymer layer is preferably formed by autopolymerization. Polymerization of substances containing at least one heavy bond, especially unsaturated fatty acids containing alkyl chains consisting preferably of 7 to 50 carbon atoms. Other substances that do not participate in polymerization may be added to the substances that participate in the polymerization reaction. The substances are preferably saturated fatty acids and fatty acid derivatives. The invention also relates to a method of manufacturing said medical product and its use.

Description

technical field [0001] The present invention relates to biocompatible coatings, methods and uses of pharmaceutical surfaces. Background technique [0002] In recent years, the implantation of vascular stents using the balloon dilatation method of occluded blood vessels has been increasingly established. Although vascular stents reduce the risk of occlusion of regenerated blood vessels, so far they have not been able to completely prevent said restenosis. [0003] No precise conceptual description of restenosis can be found in the technical literature. The most commonly used morphological definition of restenosis is the definition of restenosis after successful PTCA (Percutaneous Transluminal Coronary Angioplasty) as a reduction in vessel diameter to less than 50% of the normal vessel diameter. Therefore, this is an empirically defined value whose hemodynamic relevance and its relationship to clinicopathology lacks a substantial scientific basis. In practical experience, a...

Claims

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Application Information

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IPC IPC(8): A61L31/10A61L31/14A61L31/16A61F2/82
CPCA61L31/10A61L31/16A61L31/148A61L2300/00A61P29/00A61P35/00A61P43/00A61L31/14A61L31/08
Inventor 艾利克·霍夫曼
Owner HEMOTEQ AG
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