Self-assembly composite nano granule tumor vaccine and method for preparing same

A composite nanoparticle and tumor vaccine technology is applied in the field of self-assembled composite nanoparticle tumor vaccine and its preparation, so as to achieve the effect of attacking and inhibiting and stimulating the body's immune system.
CN1927401AInactive Publication Date: 2007-03-14INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INST OF BASIC MEDICAL SCI ACAD OF MILITARY MEDICAL SCI OF PLA
Publication Date
2007-03-14
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention relates to a self-combine compound nanometer cancer vaccine, and relative production. Wherein, said vaccine is formed by cancer cell membrane, protein molecule and DNA particle; the invention builds the cancer antigen molecule and immunologic adjuvant molecule on the eucaryon expression carrier, to anchor and express on the surface of cancer cell; then mixing the cells, to extract cell membrane, and decompose the cell membrane into the membrane liposome with anchored protein molecule, to be mixed with the DNA particles of cancer antigen molecule, immunity adjusting molecule, in certain buffer condition, to form the nanometer cancer vaccine. The invention can be used to treat several carcinomas, contagion, and non-contagion.
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Description

technical field

[0001] The invention relates to a novel therapeutic tumor vaccine, in particular to a self-assembled composite nanoparticle tumor vaccine and a preparation method thereof. Background technique

[0002] Tumor vaccine is an important method in tumor biotherapy. It stimulates the body's immune system to specifically recognize and kill tumor cells in vivo. In terms of preventing tumor recurrence and metastasis, tumor vaccines have unique advantages that cannot be compared with the three traditional treatments of surgery, chemotherapy and radiotherapy [Mocellin S, et al Cancer vaccine development: on the way to break immunetolerance to malignant cells. Exp Cell Res .2004;299(2):267-78].

[0003] Tumor vaccines have been researched and developed in the following forms: (1) Vaccines based on whole tumor cells: tumor lysates, gene-transfected tumor cells, tumor cell RNA vaccines, etc.; (2) Tumor antigen vaccines : Based on specific tumor antigens, including peptide...

Claims

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