Rutin containing medicine composition

A composition and mixture technology, applied in the composition containing natural plant extracts or monomers, functional health care products or cosmetics, and in the field of medicine, can solve the problem of limited effectiveness, difficult industrial production and quality control, and ineffective curative effect. Satisfactory etc.

Active Publication Date: 2007-03-21
YUNNAN BIOVALLEY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Unfortunately, however, the results achieved are limited and the efficacy is unsatisfactory
On the one hand, this is due to the fact that a large number of reports of adverse reactions have made people realize that the combination of chemical drugs has unavoidable side effects while exerting a highly effective therapeutic effect
On the other hand, in the existing research on the combination of plant active ingredients, rutin or its derivatives are usually used in combination with various plant active ingredients, such as ZL03141373. , Danshen, Maodongqing, Chuanxiong extract volatile oil, leech and rutin), ZL03140469 (composed of active ingredients of scutellaria breviscapus and safflower, resveratrol and its derivatives, ligustrazine and its derivatives, ferulic acid and its derivatives substances, quercetin and its derivatives, rutin and its derivatives, or any two of them), etc., such so-called "big compound products" have unclear mechanism of action, uncertain curative effect, Defects such as difficulty in industrialized production and quality control

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0182] Example 1 Capsules

[0183] Take 5g of Radix Paeoniae Rubra, crush it into a coarse powder, add 75% ethanol to reflux and extract three times, the first and second times each for 2 hours, and the third time for 1 hour, combine the extracts, concentrate under reduced pressure to about 400ml, and extract three times with n-butanol , 300ml at a time, merge the n-butanol extract, concentrate under reduced pressure to no n-butanol smell, add 200ml of water, heat to dissolve, filter, and the filtrate is spray-dried to obtain Extract I for subsequent use;

[0184] Get one part of extract, get Flos Lonicerae extract (chlorogenic acid content is not less than 50%) 1g, get rutin 200mg, add starch, magnesium stearate, mix, pack in the hard capsule. After testing, each capsule contains chlorogenic acid 500mg, paeoniflorin 100mg and rutin 200mg.

[0185] Get five parts of extract 1, get honeysuckle extract (chlorogenic acid content is not less than 50%) 100m...

Embodiment 2

[0186]Example 2 tablet

[0187] Take 5 kg of coffee beans, extract with 95% ethanol, dissolve the extract in water and extract with petroleum ether, ethyl acetate and n-butanol respectively to obtain petroleum ether, ethyl acetate and n-butanol. The ethyl acetate part was subjected to silica gel column chromatography and MCI column chromatography to obtain 8 g of dicaffeoyloxyquinic acid and 4 g of quinic acid, respectively. Then 100 mg of dicaffeoyloxy-quinic acid was dissolved in 1000 ml of water to make a 0.1% aqueous solution, heated and dissolved, mixed evenly, sealed in a medicine bottle, sterilized to produce a product, and the extract II was obtained for subsequent use.

[0188] Take two parts of extract I, one part of extract II and 200 mg of rutin of Example 1, add low-substituted hydroxypropyl cellulose, magnesium stearate, starch, microcrystalline cellulose, and follow the standard granulation and tableting process Granulation. After testing, it contains dicaffeo...

Embodiment 3

[0190] Embodiment 3 soft capsules

[0191] Get half part of extract I, five parts of extract II and 100 mg of Sophora japonica extract (70% rutin content) of Example 1, add starch and magnesium stearate, mix well, and make soft capsules according to the standard process. After testing, each capsule contains 500mg of dicaffeoylquinic acid, 50mg of paeoniflorin and 70mg of rutin.

[0192] Get half part of extract I, half part of extract II and 1 g of buckwheat leaf extract (80% rutin content) of Example 1, add starch and magnesium stearate, mix well, and make soft capsules according to the standard process. After testing, each capsule contains 50mg of dicaffeoylquinic acid, 50mg of paeoniflorin and 800mg of rutin.

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Abstract

The present invention is one kind of composition for medicine, cosmetics and health product and its preparation process and application. The composition contains plant extract or monomer as its active component. The medicine composition maybe used in preventing and treating metabolism syndrome, diabetes and its complication, cardiac and cerebral vascular diseases, senile dementia, hyperlipemia, etc. It may be also used in preparing functional health product with auxiliary functions of lowering blood fat, lowering blood sugar, lowering blood pressure, resisting oxidation and improving memory, and cosmetics with antioxidant function.

Description

technical field [0001] The present invention relates to a combination for medicine, functional health care products or cosmetics, in particular, a composition containing natural plant extracts or monomers and its application in medicine, functional health care products or cosmetics. Background technique [0002] Rutin is a flavonoid compound extracted from plants. Almost all Rutaceae and Heather plants contain rutin, mainly found in the flower buds (Sophora japonica) or fruit (Sophora japonica) of the leguminous plant Sophora japonica, the whole plant of Rutaceae plant Rutaceae, and the Eucalyptus plants of the Myrtaceae family especially Eucalyptus eucalyptus, Hypericaceae plant Eclipta whole herb, Polygonaceae plant buckwheat seedlings, Rhamnaceae plant Goucate chrysantha, Echinaceae plant wild sycamore leaves and other plants. [0003] Rutin has various biological activities, such as reducing capillary permeability, anti-inflammation, anti-virus, analgesia, anti-oxidatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/75A61K36/71A61K36/61A61K36/38A61K36/47A61K36/70A61K36/72A61K36/185A61K31/704A61K8/97A61K8/49A61K9/48A61Q19/00A61P43/00A61P3/10A61P9/00A61P25/28A61K31/192A61K31/216A61K31/352A61K35/64
Inventor 林艳和
Owner YUNNAN BIOVALLEY PHARMA CO LTD
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