Rutin containing medicine composition
A composition and mixture technology, applied in the composition containing natural plant extracts or monomers, functional health care products or cosmetics, and in the field of medicine, can solve the problem of limited effectiveness, difficult industrial production and quality control, and ineffective curative effect. Satisfactory etc.
Examples
Embodiment 1
[0182] Example 1 Capsules
[0183] Take 5g of Radix Paeoniae Rubra, crush it into a coarse powder, add 75% ethanol to reflux and extract three times, the first and second times each for 2 hours, and the third time for 1 hour, combine the extracts, concentrate under reduced pressure to about 400ml, and extract three times with n-butanol , 300ml at a time, merge the n-butanol extract, concentrate under reduced pressure to no n-butanol smell, add 200ml of water, heat to dissolve, filter, and the filtrate is spray-dried to obtain Extract I for subsequent use;
[0184] Get one part of extract, get Flos Lonicerae extract (chlorogenic acid content is not less than 50%) 1g, get rutin 200mg, add starch, magnesium stearate, mix, pack in the hard capsule. After testing, each capsule contains chlorogenic acid 500mg, paeoniflorin 100mg and rutin 200mg.
[0185] Get five parts of extract 1, get honeysuckle extract (chlorogenic acid content is not less than 50%) 100m...
Embodiment 2
[0186]Example 2 tablet
[0187] Take 5 kg of coffee beans, extract with 95% ethanol, dissolve the extract in water and extract with petroleum ether, ethyl acetate and n-butanol respectively to obtain petroleum ether, ethyl acetate and n-butanol. The ethyl acetate part was subjected to silica gel column chromatography and MCI column chromatography to obtain 8 g of dicaffeoyloxyquinic acid and 4 g of quinic acid, respectively. Then 100 mg of dicaffeoyloxy-quinic acid was dissolved in 1000 ml of water to make a 0.1% aqueous solution, heated and dissolved, mixed evenly, sealed in a medicine bottle, sterilized to produce a product, and the extract II was obtained for subsequent use.
[0188] Take two parts of extract I, one part of extract II and 200 mg of rutin of Example 1, add low-substituted hydroxypropyl cellulose, magnesium stearate, starch, microcrystalline cellulose, and follow the standard granulation and tableting process Granulation. After testing, it contains dicaffeo...
Embodiment 3
[0190] Embodiment 3 soft capsules
[0191] Get half part of extract I, five parts of extract II and 100 mg of Sophora japonica extract (70% rutin content) of Example 1, add starch and magnesium stearate, mix well, and make soft capsules according to the standard process. After testing, each capsule contains 500mg of dicaffeoylquinic acid, 50mg of paeoniflorin and 70mg of rutin.
[0192] Get half part of extract I, half part of extract II and 1 g of buckwheat leaf extract (80% rutin content) of Example 1, add starch and magnesium stearate, mix well, and make soft capsules according to the standard process. After testing, each capsule contains 50mg of dicaffeoylquinic acid, 50mg of paeoniflorin and 800mg of rutin.
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Abstract
Description
Claims
Application Information
- IPC
- A61K36/75; A61K36/71; A61K36/61; A61K36/38; A61K36/47; A61K36/70; A61K36/72; A61K36/185; A61K31/704; A61K8/97; A61K8/49; A61K9/48; A61Q19/00; A61P43/00; A61P3/10; A61P9/00; A61P25/28; A61K31/192; A61K31/216; A61K31/352; A61K35/64
- Inventors
- 林艳和