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Sarcandra glaber dispersant tablets

A technology of Zhongjiefeng and dispersible tablets is applied in the directions of antitumor drugs, medical raw materials derived from angiosperm subphylum, and pill delivery, etc., which can solve the problems such as the lack of disintegration time of Zongjiefeng dispersible tablets, and achieves great room for manoeuvre, The effect of improving disintegration

Inactive Publication Date: 2007-04-04
JIANGXI HERBFINE HI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The reported Zhongjiefeng Dispersible Tablet CN200410040994.6 has no record of specific disintegration time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] The traditional Chinese medicine raw material of Zhongjiefeng dispersible tablet: air-dried extract of Zhongjiefeng.

[0054] The weight percentage of traditional Chinese medicine extract and auxiliary materials of Zhongjiefeng Dispersible Tablets: 35.3% of fine powder of Zhongjiefeng extract, 14.5% of sodium carboxymethyl starch, 12.2% of low-substituted hydroxypropyl cellulose, and 14.2% of microcrystalline cellulose , lactose 18.5%, polyvinylpyrrolidone 3.1%, magnesium stearate 2.2%.

[0055] Zhongjiefeng Dispersible Tablets are obtained according to the following specific steps: take Zhongjiefeng, chop it up, add 8 times of water to decoct three times, each time for 1 hour, combine the decoction, filter, the filtrate is concentrated into a thick paste with a density of 1.23, and dried Dried extract, crushed to make the fine powder of Sargassum extract. First pass the above materials through a 100-mesh sieve, and mix the fine powder of Sargassum extract with filler ...

Embodiment 2

[0057] The fine powder of Sargassum extract by weight 30%, sodium carboxymethylcellulose 22%, microcrystalline cellulose 11%, cross-linked polyvinylpyrrolidone 16%, polyvinylpyrrolidone 5%, lactose 9%, polyethylene Pyrrolidone 4%, micronized silica gel 1%, magnesium lauryl sulfate 2%. All the other are with embodiment 1.

Embodiment 3

[0059] 40% by weight of fine powder of Sargassum extract, 20% sodium carboxymethyl starch, 15% croscarmellose sodium, 6% crospovidone, 3% low-substituted hydroxypropyl cellulose , mannitol 6%, polyvinylpyrrolidone 5%, micronized silica gel 3%, magnesium stearate 1%, HLB=15-16 sucrose fatty acid ester 1%. Sucrose fatty acid ester is P-1570 or P-1670 or LWA-1570, all the other are the same as embodiment 1.

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PUM

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Abstract

A dispersing tablet of glabrous sarcandra herb for treating pneumonia, appendicitis, cellular tissue inflammation, cancer, etc is prepared from the dried extract of glabrous sarcandra herb through pulverizing and mixing with auxiliary.

Description

technical field [0001] The invention relates to the technical field of dispersible tablets of Chinese patent medicine, in particular to a dispersible tablet of sargassum. Background technique [0002] Dispersible tablets are a new drug dosage form developed in recent years. There are many dosage forms of sargassum, which has the effects of clearing away heat and detoxifying, reducing swelling and dispelling stagnation. It is used for pneumonia, appendicitis, and cellulitis, which belong to the syndrome of excessive heat and toxin, and can be used for adjuvant therapy of cancer. One of the original dosage forms, sarcophagus, is a sugar-coated tablet that has been listed in the Chinese Pharmacopoeia. The dissolution of Zhongjiefeng sugar-coated tablets is slow, the absorption is poor, and the bioavailability is not high. [0003] Compared with ordinary tablets, dispersible tablets require that the temperature of the disintegration medium is 20±1°C, the disintegration time li...

Claims

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Application Information

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IPC IPC(8): A61K36/18A61K9/20A61P29/00A61P11/00A61P35/00A61P43/00
Inventor 罗晓健吕爱平王跃生傅国强王金钱文毅张爱玲
Owner JIANGXI HERBFINE HI TECH
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