Yixin ketone dispersing tablets

A technology of Yixin ketone and dispersible tablets, applied in the field of Yixin ketone dispersible tablets, can solve the problems of difficult industrialization, adhesion, high proportion and content, and achieve the effects of large room for maneuver and improvement of disintegration degree.

Inactive Publication Date: 2007-04-04
JIANGXI HERBFINE HI TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Most traditional Chinese medicine dispersible tablets contain about 30-50% of the main drug. It is not easy to rely on the remaining drug adjuvants to ensure rapid disintegration in 3 minutes and maintain a considerable dissolution rate. In addition, most of the traditional Chinese medicine extracts Macromolecular substances such as pectin and polysaccharides adhere to the surface of traditional Chinese medicine dispersible tablets when they disintegrate, causing negative effects on drug disintegration and dissolution
[0011] To sum up, most Chinese medicine dispersible tablets are difficult to control the disintegration speed of Chinese medicine dispersible tablets within 3 minutes due to (1) the high proportion of main ingredients of traditional Chinese medicine, and (2) the adhesion of macromolecular substances such as pectin and polysaccharides. It is more difficult to industrialize than western medicine dispersible tablets
There are many types of industrialized Western medicine dispersible tablets, but there are very few industrialized Chinese medicine dispersible tablets.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The weight percentage of traditional Chinese medicine extract and auxiliary materials of Yixindone dispersible tablet: 24% of fine powder of Yixindone extract, 22% of low-substituted hydroxypropyl cellulose, 20% of sodium carboxymethyl starch, and 7% of microcrystalline cellulose , lactose 21%, polyvinylpyrrolidone 3%, magnesium stearate 3%.

[0053] Yixindone dispersible tablets are obtained according to the following specific steps: take hawthorn leaves, crush them into coarse powder, use ethanol as a solvent to carry out percolation according to the percolation method under the liquid extract and extract, collect the percolation liquid, and depressurize Recover ethanol to a certain concentration, add an equal amount of water to dilute, add petroleum ether to remove the pigment, separate the water layer, shake and extract with ethyl acetate, extract the ethyl acetate under reduced pressure and concentrate to dryness to obtain total flavonoids, crush The fine powder of...

Embodiment 2

[0056] The fine powder of Yixinone extract by weight 28%, sodium carboxymethylcellulose 22%, microcrystalline cellulose 11%, cross-linked polyvinylpyrrolidone 15%, polyvinylpyrrolidone 5%, lactose 12%, polyethylene Pyrrolidone 4%, micronized silica gel 1%, magnesium lauryl sulfate 2%. All the other are with embodiment 1.

Embodiment 3

[0058] The fine powder of Yixinone extract in percentage by weight 35%, sodium carboxymethyl starch 20%, croscarmellose sodium 15%, crospovidone 6%, low-substituted hydroxypropyl cellulose 3% , mannitol 10%, polyvinylpyrrolidone 7%, micronized silica gel 1%, magnesium stearate 2%, HLB=15-16 sucrose fatty acid ester 1%. Sucrose fatty acid ester is P-1570 or P-1670 or LWA-1570, and all the other are the same as embodiment 1.

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Abstract

A 'Yixintong' dispersing tablet for treating coronary heart disease, angina pectoris, hyperlipemia, cerebral arterial blood supply insufficiency, etc is prepared from haw leaf and proper auxiliary.

Description

technical field [0001] The invention relates to the technical field of Chinese patent medicine dispersible tablets, in particular to a dispersible tablet of Yixinone. Background technique [0002] Dispersible tablets are a new drug dosage form developed in recent years. There are many dosage forms of Yixindone. It is used for qi stagnation and blood stasis, chest tightness, suffocation, palpitation, forgetfulness, dizziness and tinnitus; coronary heart disease, angina pectoris, hyperlipidemia, and cerebral arterial insufficiency belong to the above syndromes. Yixindone, one of the original dosage forms, is a sugar-coated tablet that has been listed in the Chinese Pharmacopoeia. Yixinketone sugar-coated tablets have slow dissolution, poor absorption and low bioavailability. [0003] Compared with ordinary tablets, dispersible tablets require that the temperature of the disintegration medium is 20±1°C, the disintegration time limit is less than 3 minutes, and all the disinte...

Claims

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Application Information

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IPC IPC(8): A61K36/74A61K9/20A61P9/10A61P3/06
Inventor 罗晓健王跃生吕爱平饶毅傅国强文毅张红红
Owner JIANGXI HERBFINE HI TECH
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