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A technology of black-bone chicken, white phoenix, and dispersible tablets, which is applied to medical preparations containing active ingredients, plant/algae/fungus/moss ingredients, pill delivery, etc. It can solve problems such as difficult industrialization, adhesion, and dissolution rate, etc. Achieve the effect of large room for maneuver and improved disintegration
Inactive Publication Date: 2012-03-28
JIANGXI HERBFINE HI TECH
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[0011] Most traditional Chinese medicine dispersible tablets contain about 30-50% of the main drug. It is not easy to rely on the remaining drug adjuvants to ensure rapid disintegration in 3 minutes and maintain a considerable dissolution rate. In addition, most of the traditional Chinese medicine extracts Macromolecular substances such as pectin and polysaccharides adhere to the surface of traditional Chinese medicine dispersible tablets when they disintegrate, causing negative effects on drug disintegration and dissolution
[0012] To sum up, most Chinese medicine dispersible tablets are difficult to control the disintegration speed of Chinese medicine dispersible tablets within 3 minutes due to (1) the high proportion of main ingredients of traditional Chinese medicine, and (2) the adhesion of macromolecular substances such as pectin and polysaccharides. It is more difficult to industrialize than western medicine dispersible tablets
There are many types of industrialized Western medicine dispersible tablets, but there are very few industrialized Chinese medicine dispersible tablets.
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Embodiment 1
[0057] Chinese medicine raw materials of black-bone chicken and Baifeng dispersible tablets: 750 grams of black-bone chicken (hair removal, claws, intestines), 280 grams of astragalus (honey roast), 375 grams of rehmannia glutinosa, 280 grams of codonopsis, 95 grams of Chuanxiong, 188 grams of angelica, white peony root (wine Fried) 188 grams, Schisandra (wine) 95 grams, yam 560 grams, Atractylodes macrocephala 280 grams, Poria cocos 188 grams, Moutan bark 188 grams.
[0058] The weight percentage of traditional Chinese medicine extract and auxiliary materials of Wuji Baifeng Dispersible Tablets: 20% fine powder of Wuji Baifeng extract, 25% low-substituted hydroxypropyl cellulose, 19% sodium carboxymethyl starch, 10% microcrystalline cellulose , lactose 20%, polyvinylpyrrolidone 3%, magnesium stearate 3%.
[0059] Black-bone Chicken Baifeng Dispersible Tablets are obtained according to the following specific steps: the above twelve flavors, the yam is crushed into fine powder;...
Embodiment 2
[0062] 28% by weight of fine powder of Wuji Baifeng extract, 22% sodium carboxymethylcellulose, 16% cross-linked polyvinylpyrrolidone, 12% microcrystalline cellulose, 5% polyvinylpyrrolidone, 10% lactose, polyethylene Pyrrolidone 4%, micronized silica gel 1%, magnesium lauryl sulfate 2%. All the other are with embodiment 1.
Embodiment 3
[0064] 36% by weight of fine powder of Wuji Baifeng extract, 20% sodium carboxymethyl starch, 15% croscarmellose sodium, 6% crospovidone, 3% low-substituted hydroxypropyl cellulose , mannitol 9%, polyvinylpyrrolidone 7%, micronized silica gel 2%, magnesium stearate 1%, HLB=15-16 sucrose fatty acid ester 1%. Sucrose fatty acid ester is P-1570 or P-1670 or LWA-1570, all the other are the same as embodiment 1.
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Abstract
The invention relates to an 'Wujibaifeng' dispersing tablet. The medicine comprises the raw materials of Pullus Cum Osse Nigro (removing hair, claw and intestines), milkvetch root (honeyed), rehmannia glutinosa, codonopsis pilosula, ligusticum wallichii, angelica sinensis, white paeony root (stirheating with liquor), schisandra chinensis (processing with rice wine), Chinese yam, rhizoma atractylodis macrocephalae, poria cocos and moutan bark, and the raw materials are for preparing the fines of the Wujibaifeng extracts and is added the moderate auxiliary material to produce the wujibaifeng dispersing tablet which can completely be dissolved and reaches the homodisperse state in 3 minutes, and the invention has effects of clearing deficient heat and supplying the qi and blood for women disease, such as thin body, abnormal menstruation, feverish palms and soles, leucorrhea with reddish discharge, nonstop flooding and the like. The invention is characterized in that the medicine can rapidly dissolve in water to the luscious solution which can be easily accepted and took by the patient, and the invention can be conveniently carried and used. The optimized auxiliary material of the invention can let the wujibaifeng dispersing tablet dissolving faster.
Description
technical field [0001] The invention relates to the technical field of Chinese patent medicine dispersible tablets, in particular to a dispersible tablet of black-bone chicken and white phoenix. Background technique [0002] Dispersible tablets are a new drug dosage form developed in recent years. There are many dosage forms of black-bone chicken and white phoenix, which have the functions of clearing deficiency and heat and nourishing qi and blood. It is used for thin women, irregular menstruation, heat in hands, feet, heart, leucorrhea, and metrorrhagia. One of the original dosage forms, Wuji Baifeng, is a big honeyed pill or a small honeyed pill, which has been included in the Chinese Pharmacopoeia. The dissolution of Wuji Baifeng Wan is slow, the absorption is poor, and the bioavailability is not high. [0003] Compared with ordinary tablets, dispersible tablets require that the temperature of the disintegration medium is 20±1°C, the disintegration time limit is less t...
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