Protein adsorption-preventing ocular lens material and method for producing same

A manufacturing method and protein technology, which can be used in glasses/goggles, intraocular lens, eye implants, etc., can solve the problem that the introduction reaction of phosphocholine bases cannot be fully carried out, does not show the effect of preventing protein adsorption, and is extremely difficult to obtain high yields. problems such as rate and high purity, to achieve excellent antifouling effect, improve wearing feeling, easy to control effect

Inactive Publication Date: 2007-05-02
SHISEIDO CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] However, in the method described in Patent Document 5, the synthesis of phosphorylcholine-containing compounds requires many steps and complicated methods, and it is extremely difficult to obtain the target product with high yield and high purity.
In addition, the introduction reaction of phosphorylcholine group into the surface of the contact lens cannot be sufficiently carried out under the conditions described in the above-mentioned patent documents, and the introduction amount is low, so it does not show an excellent effect of preventing protein adsorption.

Method used

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  • Protein adsorption-preventing ocular lens material and method for producing same
  • Protein adsorption-preventing ocular lens material and method for producing same
  • Protein adsorption-preventing ocular lens material and method for producing same

Examples

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Effect test

Embodiment 1

[0108] "Example 1"

[0109]One piece of Polymacon was soaked in 2 ml of water, and 10 mg of the phosphorylcholine-containing compound of formula (2) was dissolved. Next, 2ml of 2N hydrochloric acid was added to adjust the concentration of the mixed solution to 1M hydrochloric acid, and then reacted at 70° C. for 5 hours. The reaction solution was cooled to room temperature, and washed sufficiently with pure water to obtain the target contact lens. The introduced amount of the phosphorylcholine group of the formula (1) was 0.0734 mol / mg.

Embodiment 2

[0110] "Example 2"

[0111] One tablet of Nelfilcon A was soaked in 2 ml of water, and 10 mg of the phosphorylcholine-containing compound of formula (2) was dissolved. Next, 2ml of 2N hydrochloric acid was added to adjust the concentration of the mixed solution to 1M hydrochloric acid, and then reacted at 40° C. for 5 hours. The reaction solution was cooled to room temperature, and washed sufficiently with pure water to obtain the target contact lens. The introduced amount of the phosphorylcholine group of the formula (1) was 0.1688 μmol / mg.

[0112] "Method for quantifying phosphorylcholine groups of formula (1)"

[0113] The obtained contact lens is immersed in perchloric acid and heated to 180°C to decompose. The obtained solution was diluted with water, heptamolybdate hexaammonium tetrahydrate and L ascorbic acid were added thereto, the color was developed at 95°C for 5 minutes, and the amount introduced was determined by measuring the absorbance at 710 nm. The calibra...

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Abstract

Disclosed is a method for producing an ocular lens material which comprises a step for reacting and covalently bonding a compound having a phosphorylcholine group represented by the formula (1) below with the surface of an ocular lens material. This method for producing an ocular lens material is characterized in that a phosphorylcholine group-containing compound represented by the formula (2) below is reacted with an ocular lens material having an OH group in any one of water, an organic solvent and a water-organic solvent mixture, thereby being covalently bonded thereto by an acetal bond. The object of the present invention is to provide an eye lens material that prevents protein adsorption and a method of manufacturing thereof. In the formula (2), n is a natural number of 1-18.

Description

technical field [0001] The present invention relates to eyeglass materials such as contact lenses, a method for producing the same, and a method for preventing protein adsorption. More particularly, the present invention relates to methods of treating the surfaces of lens materials, especially contact lenses, to prevent proteinaceous fouling by post-treatment with phosphorylcholine-containing compounds. Background technique [0002] It is known to polymerize phosphorylcholine group-containing monomers and use them as contact lens materials (Patent Documents 1-3). For example, Patent Document 1 discloses a water-containing soft contact lens containing phosphorylcholine group-containing (meth)acrylate as a constituent unit, and it is described that the water content, oxygen permeability, and tensile strength are excellent, and the protein The amount of adsorption is small, and the adhesion of dirt can be suppressed. [0003] As a post-treatment method for contact lenses, Pat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G02C7/04A61F2/16C08J7/12C08L101/00
Inventor 石原一彦隅田如光宫泽和之
Owner SHISEIDO CO LTD
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