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Quality control method of honeysuckle, scutellarta root and extract thereof and formulation containing the extract

A quality control method, honeysuckle extract technology, applied to medical preparations containing active ingredients, measuring devices, drug combinations, etc., can solve problems such as correlation studies that have not been reported, to ensure the safety of use and control stability Effect

Inactive Publication Date: 2007-05-30
天津市轩宏医药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, studies on the fingerprints of honeysuckle and Scutellaria baicalensis have been reported, but the fingerprints of preparations containing honeysuckle extracts and Scutellaria baicalensis extracts have not been reported, and their correlation studies have not yet been reported.

Method used

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  • Quality control method of honeysuckle, scutellarta root and extract thereof and formulation containing the extract
  • Quality control method of honeysuckle, scutellarta root and extract thereof and formulation containing the extract
  • Quality control method of honeysuckle, scutellarta root and extract thereof and formulation containing the extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Embodiment one, honeysuckle medical material fingerprint collection

[0054] 1. Chromatographic conditions

[0055] laballiance high performance liquid chromatography; seriesIII binary pump; UV6000LP detector; Ezchrom Elite workstation.

[0056] Chlorogenic acid reference substance (provided by China National Institute of Pharmaceutical and Biological Products, batch number: 11075-200212); acetonitrile is chromatographically pure, and other reagents are analytically pure.

[0057] Chromatographic column: Kromasil C 18 (Ф4.6×250mm, 5um); mobile phase A: acetonitrile, mobile phase B: 0.1% phosphoric acid; using gradient elution, the elution procedure is shown in the table below; detection wavelength: 327nm; flow rate: 1.0ml / min; column temperature : 30°C; injection volume: 10ul.

[0058] time (min)

A(％)

B(％)

0

5

25

30

5

5

35

5

95

95

65

95

[0059] 2. Preparat...

Embodiment 2

[0074] Embodiment two, honeysuckle extract fingerprint

[0075] 1. Chromatographic conditions

[0076] laballiance high performance liquid chromatography; seriesIII binary pump; UV6000LP detector; Ezchrom Elite workstation.

[0077] Chlorogenic acid reference substance (provided by China National Institute of Pharmaceutical and Biological Products, batch number: 11075-200212); honeysuckle extract (self-made); acetonitrile is chromatographically pure, and the rest of the reagents are analytically pure.

[0078] Column: Kromasil C 18 (Ф4.6×250mm, 5um); mobile phase A: acetonitrile, mobile phase B: 0.1% phosphoric acid; using gradient elution, the elution procedure is shown in the table below; detection wavelength: 327nm; flow rate: 1.0ml / min; column temperature : 30°C; injection volume: 10ul.

[0079] time (min)

[0080] 2. Preparation of reference substance solution: Take 5 mg of chlorogenic acid reference substance, weigh it accurately, put it in a 100ml volumetri...

Embodiment 3

[0089] Embodiment three, Scutellaria baicalensis medicinal material fingerprint

[0090] 1. Chromatographic conditions

[0091]High-performance liquid chromatography: lab alliance seriesIII binary pump; UV6000LP detector; Ezchrom Elite workstation.

[0092] Baicalin (provided by China National Institute of Pharmaceutical and Biological Products, batch number: 11015-200212); acetonitrile was chromatographically pure, and the rest of the reagents were analytically pure.

[0093] Column: Kromasil C 18 (Ф4.6×250mm, 5um); mobile phase A: acetonitrile, mobile phase B: 0.1% phosphoric acid; using gradient elution, the elution procedure is shown in the table below; detection wavelength: 327nm; flow rate: 1.0ml / min; column temperature : 30°C; injection volume: 10ul.

[0094] time (min)

[0095] 2. Preparation of reference substance solution: Take 6 mg of baicalin reference substance, weigh it accurately, put it in a 100ml volumetric flask, add methanol to dissolve and dilu...

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Abstract

The invention relates to a medicinal extract of honeysuckle and scutellaria root, and the quality control method for preparations containing honeysuckle extract and scutellaria root extract, which comprises employing high temperature liquid chromatography to establish a series of fingerprint patterns of honeysuckle flower, honeysuckle flower extract, baikal skullcap root herbs and extract, and preparations containing honeysuckle extract and scutellaria root extract from raw material to final preparations, then investigating the correlation between the patterns.

Description

technical field [0001] The present invention relates to a method for quality control of raw medicinal materials, their extracts and preparations containing the extracts, more specifically to a kind of honeysuckle medicinal materials, Scutellaria baicalensis medicinal materials, their extracts and preparations containing honeysuckle extracts and Scutellaria baicalensis extracts quality control methods. technical background [0002] Lonicera japonica Thunb., Lonicera hypoglauca Miq., Lonicera confusa DC. or Lonicera dasystyla Rehd. are the dry buds or flowers of Lonicera dasystyla Rehd. It has the functions of clearing heat, detoxifying, cooling The effect of dispelling wind and heat is mainly used for carbuncle, furuncle, sore throat, erysipelas, toxic dysentery due to hot blood, fever due to febrile disease, etc. Scutellaria baicalensis is the dried root of Scutellaria baicalensis Georgi, a plant of the Labiatae family, which has the functions of clearing away heat, drying d...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/539A61P11/04A61P11/14G01N30/02G01N30/36
Inventor 石秀伟孔志云
Owner 天津市轩宏医药技术有限公司
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