Methods and compositions comprising bacteriophage nanoparticles

A composition and phage technology, applied in the field of T4 phage, can solve problems such as inability to package DNA, difficulty in copy number, inability to use stimulation-strengthening strategies, etc., and achieve reliable production effects
CN1972710AActive Publication Date: 2007-05-30CATHOLIC UNIV OF AMERICA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
CATHOLIC UNIV OF AMERICA
Publication Date
2007-05-30

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Abstract

Compositions and methods comprising bacteriophages are provided. In particular, the present invention includes novel and customized T4 bacteriophages uniquely designed for effective antigen and foreign particle presentation. The present invention also provides in vitro methods for the making of customized T4 bacteriophages. The compositions and methods of the present invention may be used for effective vaccine delivery systems.
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Description

field of invention

[0001] The present invention relates to novel methods and compositions comprising bacteriophage. More specifically, the present invention includes novel and custom T4 phages uniquely designed for efficient antigen and foreign particle presentation. The methods and compositions of the invention can be used in efficient vaccine delivery systems. Background of the invention

[0002] In phage display, foreign peptides, domains or proteins are fused to structural proteins and exposed on the outer surface of the phage capsid (Smith, 1985). The coat proteins (M13, fd, and fl), the small coat protein pIII (4–5 copies), and the large coat protein pVIII (2700 copies) of filamentous bacteriophage have been widely used to generate A combinatorial library of peptides from ® (Smith and Petrenko, 1997; Manoutcharian et al., 2001). Other display systems using icosahedral phages lambda and T7 have also been developed (Maruyama et al., 1994; Danner and Belasco, 2001). T...

Claims

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