Medicinal composition of astragalus, salvia miltrorrhiza and oxymatrine, and its preparing method

A composition and matrine technology, applied in the field of medicine to achieve the effect of meeting clinical needs

Inactive Publication Date: 2007-06-13
海安江理工技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, using the interaction of astragalus or its extracts, Danshen or its extracts and matrine, and compatible prescriptions to prepare drugs for the treatment of liver diseases has not been reported.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0140] The preparation and identification and content determination of the total saponins of astragalus of embodiment 1

[0141] Preparation of Astragalus Total Saponins

[0142] Take the Astragalus medicinal material, add water and decoct three times, 1.5 hours each time, add 10 times the amount of water for the first time, and 8 times the amount for the second and third times, combine the decoction, filter, and concentrate the filtrate to a relative density of 1.20-1.25 (60°C ), with ethanol precipitation treatment 2 times, the alcohol content in the solution for the first time is 75%, and the second time is 85%, each time it is placed in cold storage, the ethanol is reclaimed and concentrated to the equivalent of 10g of the original medicinal material per 1ml, added to already On the treated macroporous adsorption resin column, wash the column with 2 times the volume of water, then elute with 4 times the volume of 70% ethanol, collect the eluate, concentrate under reduced...

Embodiment 2

[0162] Example 2 Preparation, Identification and Content Determination of Astragalus Polysaccharide

[0163] Preparation of astragalus polysaccharide

[0164] Take the Radix Astragali medicinal material, add 7 times the amount of 70% ethanol to extract twice, each time for 2 hours, discard the extract, take the dregs and add water to extract twice, combine the extract, concentrate until the ratio of the volume of the extract to the raw medicinal material is 1.05: 1. Add ethanol to precipitate to make the alcohol content reach 70%, filter to obtain a precipitate, wash the precipitate with 70% ethanol, dissolve it with an appropriate amount of water, filter, pass the filtrate through a macroporous resin, elute with water, collect the washing liquid, and put Concentrate the washing solution until the ratio of the volume of the medicinal solution to the medicinal material is 1:2.5, add ethanol to make the alcohol content reach 70%, and obtain a precipitate, wash and dehydrate th...

Embodiment 3

[0178] The preparation and identification and content determination of the total phenolic acid of salvia miltiorrhiza in embodiment 3

[0179] Preparation of total phenolic acid of salvia miltiorrhiza

[0180] Take the Danshen medicinal material, crush it into coarse grains, add water and decoct three times, add 12 times the amount of water for the first 2 hours, add 10 times the amount of water for the second and third times each for 1.5 hours, combine the decoction, filter, and concentrate the filtrate under reduced pressure to The relative density is 1.17~1.20. Add ethanol for precipitation twice, the first time to make the alcohol content to 75%, the second time to make the alcohol content to 85%, each stand for 24 hours, recover the ethanol until the relative density is 1.17-1.20, and spray dry to obtain.

[0181] Three batches of total phenolic acids of Salvia miltiorrhiza were prepared respectively, and the yields are shown in Table 2-3.

[0182] Identification of S...

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PUM

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Abstract

The present invention discloses a new medicine composition for curing hepatic diseases and its preparation method. It is formed from (by weight portion) 400-10000 portions of astragalus root, 200-6000 portions of salvia root and 10-200 portions of kurarinone, and also can be made up by using 2-200 portions of astragalus total saponin or astragalus polysaccharide, 2-200 portions of salvia total phenolic acid and 10-200 portions of kurarinone. Said medicine composition can be made into various dosage forms of oral preparation, injection and others. Said medicine composition can be used for curing diseases of viral hepatitis, medicamentous liver lesion, fatty liver and alcoholic hepatitis, etc.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition mainly made of astragalus or its extract, salvia miltiorrhiza or its extract and matrine, and a preparation method thereof. 2. Background technology [0002] Hepatitis is a common and frequently-occurring disease. According to incomplete statistics, hepatitis patients and virus carriers account for 10% of the total population in my country. Among them, viral hepatitis is the main one, and viral hepatitis can be divided into: acute hepatitis, chronic hepatitis, severe hepatitis and biliary hepatitis. Hepatitis is a kind of infectious disease, because of its widespread prevalence, great harm, and high incidence rate, it is one of the difficult diseases recognized both at home and abroad. China is a high prevalence area of ​​hepatitis B, more than 40% of people have been infected by hepatitis B virus (HBV), and more than 100 million people are chronic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K31/4375A61K31/715A61P1/16A61P31/12A61P31/20
Inventor 黄振华
Owner 海安江理工技术转移中心有限公司
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