Scutellarein derivative, its preparing process and application

A kind of technology of baicalein and derivatives, applied in the field of baicalein derivatives
CN1990481AInactive Publication Date: 2007-07-04SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
Publication Date
2007-07-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a novel scutellarein derivative, the method for preparing the same and the application. It is proved through pharmacological test that the compound possesses obvious effect against lipid peroxidation, effect against cell damage induced by H2O2 and cell apoptosis induced by A beta, it can also inhibit Cu2+ from inducing oxidation and modification for low density lipoprotein. The compound can be used to prepare medicine that can prevent or treat neurodegenerative diseases such as Alzheimer's disease caused by free radical oxidation, and medicine that can treat inflammation, reduce blood fat and treat atherosclerosis.
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Description

technical field

[0001] The present invention relates to a class of novel baicalein derivatives, in particular to the application of a class of drugs for treating neurodegenerative diseases such as Alzheimer's disease, anti-inflammation, lowering blood fat and treating atherosclerosis. Background technique

[0002] Free radicals are closely related to diseases. When the production and removal of free radicals in the body are out of balance, excessive free radicals will cause damage to DNA, sugars, proteins and lipids, thereby causing a series of diseases such as aging, cardiovascular diseases, etc. Compounds of oxidative nature are likely to be effective in the prevention and treatment of these diseases. Searching for and screening drugs that can block free radical formation or scavenge free radicals has attracted more and more attention.

[0003] Baicalein is a main active ingredient of Scutellaria baicalensis, a traditional Chinese medicine, which has various physiologica...

Claims

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