Topical anesthetic formulation

Abstract

The topical medicament gel formulation of the present invention includes an anesthetic, an anti-microbial, an oxidant, a nutrient, a diuretic, an opioid, an anti-emetic, an anti-seizure drug, and a non-steroidal anti-inflammatory drug (NSAID), USP in a molecular, as opposed to a salt form, as the active ingredient. Additional constituents illustratively include a skin penetration enhancer and a gelling agent. This invention deals with problems commonly associated with topical application of local medicaments such as: slow onset of action; need for occlusion; and rapid loss of effect due to rapid systemic dispersion. The invention permits enhanced penetration of the medicament and thereby allows for a lesser total dosage of pharmaceutically active ingredient. The use of a lesser total dosage also decreases systemic toxicity.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation-in-part of U.S. application Ser. No. 10 / 645,951 filed Aug. 22, 2003, now pending, which is a continuation-in-part of U.S. application Ser. No. 10 / 111,241 filed Jul. 10, 2002, now pending, which is the U.S. National Phase of PCT Application No. PCT / US00 / 41451 filed Oct. 23, 2000, now abandoned, which claims priority of U.S. Application No. 60 / 161,155 filed Oct. 22, 1999.FIELD OF THE INVENTION[0002]The present invention generally relates to transdermal medicaments, and in particular to a fast acting transdermal medicament delivery for penetration through the stratum corneum into the deep epidermis / dermis and is especially well suited for local anesthesia.BACKGROUND OF THE INVENTION[0003]The use of topical or dermal medicaments has long been utilized in the practice of medicine. In particular, topical anesthetics are commonly administered prior to painful medical procedures such as injections, biopsies, and...

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