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Hydrophilic material and process for producing the same

a technology of hydrophilic materials and hydrophilic polymers, which is applied in the field of polymer materials, can solve the problems that the combination of hydrophilic polymers, such as polyvinylpyrrolidone, alone is not significantly effective in controlling the activation of blood platelets, and achieves the effect of eliminating the defect of conventional materials

Inactive Publication Date: 2004-12-09
TORAY IND INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a method for producing a hydrophilic substance that does not allow blood platelets to adhere to it. This is achieved by irradiating a polyvinylpyrrolidone-containing material with a cationic polymer, such as polyvinylpyrrolidone and a cationic polymer. The resulting hydrophilic substance contains a polyvinylpyrrolidone component that is stable and does not easily adhere to other materials. The hydrophilic substance can be used in various forms, such as a tube, bead, fabric, nonwoven fabric, and more. The invention solves the problem of blood platelet adhesion to hydrophilic materials and provides a better method for producing them.

Problems solved by technology

Blending with a hydrophilic polymer, such as polyvinylpyrrolidone, alone is not significantly effective in controlling the activation of blood platelets.

Method used

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  • Hydrophilic material and process for producing the same
  • Hydrophilic material and process for producing the same

Examples

Experimental program
Comparison scheme
Effect test

example 2

[0056] A hollow fiber membranes produced by the same procedure as in Example 1 was put in a 1 wt % polyethyleneimine (Aldrich reagent, molecular weight 600) solution and irradiated with gamma ray. The gamma ray absorbed dose was 29 kGy. The number of blood platelets adsorbed by the hollow fiber membrane is shown in Table 1.

example 3

[0057] A hollow fiber membranes produced by the same procedure as in Example 1 was put in a 1 wt % diethylaminoethyl dextrane (supplied by Sigma, molecular weight 500,000) solution and irradiated with gamma ray. The gamma ray absorbed dose was 29 kGy. The number of blood platelets adsorbed by the hollow fiber membrane is shown in Table 1.

example 4

[0065] Polysulfone film 1 was put in a 0.1 wt % polyethyleneimine (supplied by Sigma, molecular weight 750,000) solution and irradiated with gamma ray. The gamma ray absorbed dose was 29 kGy. The film was in an insoluble state. The film was then rinsed with purified water, stirred in 80.degree. C. purified water for 60 min, and after replacing the purified water, stirred at 80.degree. C. for another 60 min. The purified water was replaced again and stirring was performed at 80.degree. C. for another 60 min to ensure complete removal of adsorbed polyethyleneimide. The number of blood platelets adsorbed by the film is shown in Table 1.

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Abstract

The present invention relates to a hydrophilic substance production method characterized in that polyvinylpyrrolidone-containing material wetted with an aqueous solution of a cationic polymer is treated with radiation. The invention makes it possible to produce material for blood treatment that prevents adsorption of blood platelets.

Description

[0001] The present invention relates to a hydrophilic substance and a production method thereof, particularly to a hydrophilic substance with resistance to adsorption of blood platelets, and a production method thereof. Consisting of a cationic polymer component, it is suited to uses that take advantage of good features of a cationic polymer.PRIOR ART[0002] A variety of polymer materials are presently used in the medical field. When used in artificial blood vessels, catheters, artificial kidneys, or other products that directly contact with blood, serious problems can arise with adhesion of blood components, such as plasma protein and blood platelets, and resultant formation of blood clots. A separation membrane used for blood purification, for example, may suffer problems with blood residue on the membrane that results from the activation of blood platelets. To avoid such blood residue, hydrophilic substances that do not adsorb blood platelets significantly have been strongly sough...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61L33/00A61M1/36B01D67/00B01D69/02B01D71/68B01D71/82D06M10/10
CPCA61L33/0035B01D67/0011B01D67/0088B01D67/009B01D67/0093B01D69/02B01D71/68C08L81/06C08L39/06B01D69/08B01D2323/34B01D2325/28B01D2325/36B01D2323/30A61M1/3673B01D67/00111A61L29/04
Inventor SUGAYA, HIROYUKIEIKA, YOSHIHIROUENO, YOSHIYUKI
Owner TORAY IND INC
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