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Systems and methods using multiple solvents for the removal of lipids from fluids

a technology of fluids and solvents, applied in the field of systems, apparatuses and methods for the removal of lipids from fluids, can solve the problems of lipid-protein structure, insoluble lipid particles, and inability to remove lipids from fluids, and achieve the effect of reducing the amount of tim

Inactive Publication Date: 2005-01-27
ELI LILLY & CO
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patent describes a system for removing lipids from fluids and organisms using multiple solvents. The system includes a system for contacting the fluid with a first extraction solvent, which causes the lipids to separate from the fluid and dissolve in the solvent. The first solvent is then removed from the fluid using a second extraction solvent, which removes any remaining lipids. The system can be used in a continuous manner and does not require withdrawing a significant amount of blood from the patient. The technical effect of this invention is to provide a method for reducing the concentration of lipids in fluids and organisms without causing undesirable effects in the patient.

Problems solved by technology

The solvent disrupts the lipid-protein structure and frees the lipid particles, which are not very soluble in the fluid.

Method used

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  • Systems and methods using multiple solvents for the removal of lipids from fluids
  • Systems and methods using multiple solvents for the removal of lipids from fluids
  • Systems and methods using multiple solvents for the removal of lipids from fluids

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Experimental program
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Effect test

first embodiment

A. FIRST EMBODIMENT

1. Initial Phase Subsystem

FIG. 2 shows a delipidation system 10 composed of an initial phase subsystem 12 and an intermediate phase subsystem 14, and FIGS. 9 and 10 show two embodiments of a final phase subsystem 16. Referring to FIG. 2, initial phase subsystem 12 is formed with a HFC 18. While the embodiment depicted in FIG. 2, shows a single HFC, the initial phase subsystem 12 is not limited to a single HFC but may include additional HFCs. The number of HFCs used in each subsystem may be dictated by the amount of lipid removal desired. The number and size of the HFCs are a function of the flow rate of fluids or gases within, the lumens of the hollow fibers and on the shell side of the hollow fibers of the HFC, the porosity of the hollow fibers, and the amount of surface area of the hollow fiber membrane. Adjusting one of these factors requires the other factors be changed in order to yield the same output at the same rate. Additionally, patients having higher ...

second embodiment

B. SECOND EMBODIMENT

1. Initial Phase Subsystem

FIG. 11 depicts an initial phase subsystem 12 composed of a DTC 220 for contacting a first extraction solvent with a fluid containing lipids or lipid-containing organisms, or both, and for removing at least a portion of the total concentration of lipids from the fluid. While FIG. 11 shows a single DTC, initial phase subsystem 12 may be composed of one or more DTCs coupled in series or parallel or any combination thereof. DTC 220 may be configured as shown in FIG. 5.

DTC 220 is in fluid communication with a fluid source 222 for receiving a fluid. Fluid source 222 may be positioned to feed the fluid to DTC 220 using gravity flow, a vacuum, a pump 224, which may be a peristaltic pump or other pump not having vanes that contact the fluid being pumped, or other means. DTC 220 contains a first extraction solvent supplied by first extraction solvent source 226 via gravity, a vacuum, pump 228, which may be a peristaltic pump, centrifugal pump...

third embodiment

C. THIRD EMBODIMENT

1. General Description

FIG. 12 depicts a portion of another embodiment of delipidation system 10 which includes initial phase subsystem and intermediate phase subsystem. This embodiment may be used together with the final phase subsystems shown in FIGS. 9 and 10 as described in more detail below. Unlike the previous systems described above, this embodiment does not use different apparatuses to complete the initial and intermediate phases of the delipidation process. Rather, this embodiment uses a single apparatus for completing the initial and intermediate phases of the delipidation process.

Specifically, FIG. 12 depicts in-line static mixers 270 and 272 coupled to both inlet and outlet sides of a vortexer 274. In-line static mixers 270 and 272 may be formed from many designs, but typically include single or multiple tubes containing one or more flow vanes along their length. Further, this embodiment is not limited to two in-line static mixers, but may comprise ...

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Abstract

This invention is directed to systems and methods for removing lipids from a fluid or from lipid-containing organisms from a fluid, such as plasma. These systems combine a fluid with at least one extraction solvent, which causes the lipids to separate from the fluid or from the lipid-containing organisms. The separated lipids are removed from the fluid. The at least one extraction solvent is removed from the fluid or at least reduced to a concentration enabling the fluid to be administered to a patient without undesirable consequences. Once the fluid has been processed, the fluid may be administered to a patient who donated the fluid or to a different patient for therapy.

Description

FIELD OF THE INVENTION The present invention relates to systems, apparatuses and methods for the removal of lipids from fluids, especially blood plasma, or from lipid-containing organisms, or both, using extraction solvents. After being processed, the fluid may be administered to an animal or human for therapeutic use such as treatment of arteriosclerosis and atherosclerotic vascular diseases, removal of fat within an animal or human, and reduction of infectivity of lipid-containing organisms. BACKGROUND OF THE INVENTION Hyperlipidemia and Arteriosclerosis Cardiovascular, cerebrovascular, and peripheral vascular diseases are responsible for a significant number of deaths annually in many industrialized countries. One of the most common pathological processes underlying these diseases is arteriosclerosis. Arteriosclerosis is characterized by lesions, which begin as localized fatty thickenings in the inner aspects of blood vessels supplying blood to the heart, brain, and other orga...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61M1/34B01D61/36
CPCA61M1/34A61M1/342A61M1/3472A61M1/3496A61M1/3693A61M1/3486A61M2202/08A61M2202/203A61M2202/206B01D61/362A61M1/3482A61M2202/0456A61M1/3616A61M1/3403A61M2205/3306A61M2205/3334A61M2205/3331
Inventor BOMBERGER, DAVID C.CHAVEZ, BRYANGARCIA, PABLO E.HEGWER, ERICLOW, THOMAS P.MALHOTRA, RIPUDAMANSHIMON, JEFFREY J.
Owner ELI LILLY & CO