Identification of a unique core domain of Par-4 sufficient for selective apoptosis induction in cancer cells

a core domain and par-4 technology, applied in the field of prostate apoptosis response4 (par4) mutants, can solve the problems of difficult treatment of cancer, ineffective cancer treatment, and death of hundreds of thousands of people each year
US20050118179A1Active Publication Date: 2005-06-02UNIV OF KENTUCKY RES FOUND
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Patent Information

Authority / Receiving Office
US Ā· United States
Current Assignee / Owner
UNIV OF KENTUCKY RES FOUND
Publication Date
2005-06-02

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Abstract

The present invention relates to Par-4 mutants which cause apoptosis in cancer cells which are sensitive to Par-4 and also induce apoptosis in cancer cells which are resistant to Par-4. The present invention also relates to methods of using the Par-4 mutant to treat certain cancers, as well as to kits, vectors, and polypeptides for same.
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Description

CROSS-REFERENCE TO RELATED APPLICATIONS

[0001] This application claims priority under 35 U.S.C. Ā§ 119 to U.S. Provisional Application No. 60 / 430,669 entitled ā€œIdentification of a Unique Core Domain of Par-4 Sufficient for Selective Apoptosis Induction in Cancer Cellsā€ filed Dec. 4, 2002, the entire content of which is hereby incorporated by reference in its entirety.IDENTIFICATION OF FEDERAL FUNDING

[0002] The present invention was supported by NIH / NCl R01 grants CA60872 and CA84511, and therefore the government may have rights in the invention.FIELD OF THE INVENTION

[0003] The present invention relates to prostate apoptosis response-4 (Par-4) mutants which cause apoptosis in cancer cells which are sensitive to Par-4 and also induce apoptosis in cancer cells which are resistant to Par-4. The present invention also relates to methods of using the Par-4 mutant to treat certain cancers, as well as to kits, vectors, and polypeptides for same. BACKGROUND OF THE INVENTION

[0004] These mut...

Claims

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