Methods of assessing the need for and the effectiveness of therapy with antioxidants

a technology of antioxidants and need, applied in the field of need and effectiveness assessment of therapy with antioxidants, can solve the problems of limiting the patient's exposure to the drug, difficult to establish a cause and effect relationship between free radical-generating agents or conditions and disease pathology, and various treatment strategies with anti-oxidants are difficult to monitor, so as to increase glutathione synthesis or re-synthesis, and measure the utilization efficiency of anti-oxidants

Inactive Publication Date: 2005-09-15
CRUM ALBERT
View PDF14 Cites 41 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0012] In its broadest aspect, the present invention relates to methods for assessing the need of a subject for treatment with an antioxidant, or alternatively, if a subject is currently being treated with an anti-oxidant, the invention provides for measuring the utilization efficiency of the anti-oxidant and the subsequent effectiveness of therapy with the anti-oxidant. It is also an

Problems solved by technology

Certain anti-neoplastic drugs such as adriamycin and bleomycin induce severe oxidative damage, especially to the heart, limiting the patient's exposure to the drug.
Radiation poisoning from industrial sources, including leaks from nuclear reactors and exposure to nuclear weapons, are other sources of radiation and radical damage.
Until recently, the lack of specific and dependable methods for evaluating oxidant stress in vivo made it very difficult to establish a cause and effect relationship between free radical-generating agents or conditions and disease pathology.
Furthermore, the various treatment strategies with anti-oxidants have been difficult to monitor due to the lack of techniques sufficiently sensitive to reliably provide an index

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Methods of assessing the need for and the effectiveness of therapy with antioxidants
  • Methods of assessing the need for and the effectiveness of therapy with antioxidants

Examples

Experimental program
Comparison scheme
Effect test

example 1

Assessment of the Effects of IMMUNE FORMULATION 100™ or 200™ on Adriamycin Induced Oxidative Stress Levels in Rats

[0264] Adriamycin, while being an effective anti-cancer agent in humans, is known to induce nephropathy in a rat model (Zima, T. et al (1998), Nephrol. Dial. Transplant, 13: 1975-1979). Its deleterious effects on the kidney are believed to be due in part on the generation of reactive oxygen species (ROS) following its metabolism in vivo. Thus, the administration of adriamycin in a rat model provides an opportunity to study the effects of this compound on the generation of reactive oxygen species by measuring the by-products of such ROS, such as urinary lipid peroxides and pyroglutamic acid, as well as plasma glutathione. Furthermore, one can also use this model to look at the effects of this toxic compound on kidney damage, and on numbers of immune cell populations and on natural killer cell activity. In addition, this model provides an opportunity to assess the need fo...

example 2

IMMUNE FORMULATION 100™ Tablet Formulation

[0277]

Ingredients:Whey (PROLIANT ™ 8010 or 8200)1 gmColostrum1 gmSelenium methionine5 μg

[0278] Blend the ingredients together and pass through a 60 mesh screen and tumble until the components are thoroughly mixed. Compress using a 7 / 16 inch standard concave punch.

example 3

IMMUNE FORMULATION 100™ Powder Formulation

[0279]

Ingredients:Whey (Proliant ™ 8010 or 8200)75 gmColostrum25 mgSelenium methionine15 μg

[0280] Thoroughly mix the ingredients in a blender and pass through a 80 mesh screen.

[0281] This powder may be used for mixing with animal feeds, frostings, fruit spreads and beverages to be pasteurized.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Timeaaaaaaaaaa
Surfaceaaaaaaaaaa
Efficiencyaaaaaaaaaa
Login to view more

Abstract

The invention relates to diagnostic methods for assessing the need of a subject for treatment with an anti-oxidant, or alternatively, for determining the utilization efficiency and ultimate effectiveness of anti-oxidant therapy in subjects having been treated with antioxidants. More specifically, the methods of the present invention are particularly useful in prophylactic assessment of individuals at risk for developing diseases or conditions in which oxidative stress plays a role, such that an appropriate therapeutic regimen can be prescribed for that individual, thus leading to alternative therapies and/or life style changes. The invention further relates to methods for assessing the need for, the utilization efficiency and the effectiveness of therapy in subjects having received therapy with specific antioxidant and immune enhancing formulations. Kits are also provided for measuring the levels of markers of oxidative stress and immune cell numbers.

Description

FIELD OF THE INVENTION [0001] The invention relates to diagnostic methods for assessing the need of a subject for treatment with an anti-oxidant, or alternatively, for determining the effectiveness of anti-oxidant therapy in subjects having been treated with antioxidants. More specifically, it relates to methods for assessing the need for, or effectiveness of therapy in subjects having received therapy with, specific antioxidant and immune enhancing formulations. BACKGROUND OF THE INVENTION [0002] It is generally recognized that many disease processes are attributed to the presence of elevated levels of free radicals and reactive oxygen species (ROS) and reactive nitrogen species (RNS), such as superoxide, hydrogen peroxide, singlet oxygen, peroxynitrite, hydroxyl radicals, hypochlorous acid (and other hypohalous acids) and nitric oxide. [0003] In the eye, cataract, macular degeneration and degenerative retinal damage are attributed to ROS. Among other organs and their ROS-related d...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K38/05C12Q1/32G01N33/00
CPCG01N33/6806G01N2800/52G01N33/92G01N33/6815G01N33/493A61P43/00A61K31/095A61K31/198A61P39/06G01N33/6812G01N2800/7009
Inventor CRUM, ALBERT
Owner CRUM ALBERT
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap