Methods for enhancing wound healing

a wound healing and wound technology, applied in the field of wound healing enhancement, can solve the problems of increasing skin tension and affecting wound healing, affecting wound healing, and etiology of skin tension lines, and achieves the effects of reducing scar formation, reducing skin tension, and reducing scar formation

Inactive Publication Date: 2006-02-23
MAYO FOUND FOR MEDICAL EDUCATION & RES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0007] The invention is based, in part, on a new therapy for management of both traumatic and iatrogenic wounds, which includes the elimination of the tension acting on the wound. The new therapy includes injection of a chemodenervating agent to paralyze muscles capable of exerting tension on such wounds, providing better wound healing with minimal scar development. In addition, early immobilization in elective procedures also allows a surgeon to use finer sutures, further improving the cosmetic result.

Problems solved by technology

The etiology of skin tension lines, first described more than a century ago, has been subject to controversy over the years.
Increased skin tension has a negative effect on wound healing, causing hypertrophic scars or wound dehiscence.
As a consequence, extracellular deposition of collagen and glycosaminoglycans can intensify and lead to hypertrophic scars.

Method used

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  • Methods for enhancing wound healing

Examples

Experimental program
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Effect test

example 1

Would Healing by Injection of a Chemodenervating Agen in Monkeys

[0029] In order to closely mimic the effects of muscle activity on human facial skin wounds, the use of an appropriate animal model was mandatory. Due to extensive skin laxity and inadequate mimetic musculature, established models like rats, pigs, and horses, were not ideal for this purpose. Cynomolgus macaque monkeys (Macaca fascicularis) were chosen as a model since the anatomy of their cranio facial and cutaneous anatomy resembles that of humans.

[0030] The study was approved by the Institutional Committee of Animal Care and Use at the Mayo Clinic and the animals were housed, cared for, and fed in compliance with the institutional guidelines. No animal was sacrificed. All procedures were performed with anesthesia consisting of Ketamine at 20 mg / kg IM (Ketaset.RTM., Fort Dodge), Xylazine at 0.5 mg / kg IM (Rompun.RTM., Bayer), and Isoflurane at 1% (Isoflurane.RTM., Abbott).

[0031] The forehead was chosen for the excision ...

example 2

Wound Healing by Botulinum Toxin A Injection in Humans

[0041] A male patient (26 years of age, 82 kg) underwent scar revision excision surgery. The scar was located on the forehead approximately 2 cm lateral of the midline on the left, and approximately 3 cm cranial to the most superior extension of the orbital rim. Its direction was horizontal, giving it a favorable position relative to the wrinkle lines. The scar was a result of a trauma at age seven, and was closed at a tertiary referral center at the time.

[0042] The patient was placed in a supine position, and 5 ml of 0.5% lidocaine with 1:200,000 epinephrine was locally injected. The scar was excised and bleeding was controlled with monopolar cautery. Botulinum toxin A was injected (10 units) into the frontalis muscle under direct vision fanning out from the wound. The wound was closed using 6-0 Vicryl for deep and 6-0 Nylon for superficial sutures. An additional 7.5 units of botulinum toxin A were injected into the procerus and...

example 3

n of Scars from Patients Injected with a Chemodenervating Agent Alone or in Combination with a Local Anesthetic

[0044] Healthy volunteers were informed about potential risks and side effects of the treatment. Formal written informed consent was obtained in accordance with the Mayo Institutional Review Board regulations. Prior to enrollment in the study, symmetry of frontalis, procerus, and corrugator supercilii function was assessed and subjects were only included in the study if there was no functional asymmetry present. The forehead of the subjects was divided by the midline into two symmetric sides, one serving as the control and the other as the experiment side. The side of the forehead which was to serve as control was determined randomly, and was injected with Botulinum Toxin A (Botox) reconstituted in 0.9% saline. The experimental side was injected with Botulinum Toxin A reconstituted in 1% or 2% lidocaine with 1:100,000 epinephrine. The combination of these agents with Botuli...

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Abstract

Abstract of the DisclosureA method for treating a patient having a wound is described. The method includes administering an amount of a chemodenervating agent such that healing of the wound is enhanced. The method is illustrated by detailing the mean differences of the scores of the paired experimental and control scars across three observers.

Description

Detailed Description of the InventionCROSS REFERENCE TO RELATED APPLICATIONS[0001] This application is a continuation of U.S. Application Serial No. 09 / 995,022, filed November 26, 2001, which is a divisional of U.S. Application Serial No. 09 / 807,793, filed April 18, 2001, now U.S. Patent No. 6,447,787, which is a 35 U.S.C. §371 application of PCT / US99 / 24182, which claims priority from U.S. Application Serial No. 60 / 105,688, filed October 27, 1998, all of which are incorporated herein by reference.TECHNICAL FIELD[0002] The invention relates to a method for enhancing wound healing.BACKGROUND OF THE INVENTION[0003] Immobilization is a basic therapeutic principle in wound healing, common to the treatment of lesions of all kinds. Casts, plates, and sutures minimize the negative effects of muscle tension on healing tissues. Since tension is one of the chief factors determining the degree of scar formation, this principle also holds true in skin lesions. The carefully-planned execution of ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K39/08A61K31/519A61K31/335A61K31/137A61K45/00A61K31/167A61K31/445A61K31/505A61K31/529A61K38/00A61K38/16A61P17/02
CPCA61K31/335A61K31/505A61K31/519A61K31/529A61K38/164A61K38/4886A61K2300/00A61P17/02A61K39/08
Inventor GASSNER, HOLGER G.SHERRIS, DAVID A.
Owner MAYO FOUND FOR MEDICAL EDUCATION & RES
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