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Method and composition for burned skin

a technology of burnt skin and composition, applied in the field of method and composition for burnt skin, can solve the problems of progressive ischemic damage to the skin tissue, reduced blood perfusion and tissue necrosis, and reduced tissue necrosis

Inactive Publication Date: 2007-09-27
YISSUM RES DEV CO OF THE HEBREWUNIVERSITY OF JERUSALEM LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention relates to a composition for treating burns using ethyl alcohol, isopropyl alcohol, or a mixture of both, in combination with a topically acceptable polymeric carrier. The composition can prevent the development of burns, reduce the size of burns, decrease the severity of burns, increase the speed of healing, decrease pain or scarring from burns, and can be in the form of a gel, cream, emulsion, lotion, suspension, liposomes, ethosomes, microcapsules or microspheres. The composition can also contain additional agents such as urea, plants-derived materials, and other ingredients like local anesthetics, antibiotics, plant extracts, vitamins, growth factors, proteins, histamine, carnosine, insulin, anti-inflammatory agents, antiseptic agents, antifungal agents, anticytokine agents, interleukins, growth hormones, and re-epithelization factors.

Problems solved by technology

These responses lead to progressive ischemic damage to the skin tissue, reduced blood perfusion and tissue necrosis.

Method used

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  • Method and composition for burned skin
  • Method and composition for burned skin
  • Method and composition for burned skin

Examples

Experimental program
Comparison scheme
Effect test

example 1

Carbomer Gelled Matrix Containing Ethanol 35% w / w

[0065]

% w / wEthanol35Ammonium hydroxide sol (10%)4Carbopol 9402.2Water for injectionto 100

[0066] The preparation was kept refrigerated (+4 degrees Celsius) until use.

[0067] Composition 1 was applied to a second degree burn (as a result of short contact with 175° C. hot oven) on the skin of left hand of a 30 years aged female and remained on the skin for about one hour. This treatment completely impeded the development of the burn.

example 2

Composition to Stop Burn Wound Progress

[0068]

% w / wEthanolic plant extracts10Ammonium hydroxide 10% solution2Ethyl alcohol22Carbomer1DDW65

example 3

Composition to Stop Burn Wound Progress

[0069]

% w / wAmmonium hydroxide 10% solution3Alcoholic Aloe Vera Gel57 Carbopol 9341Purified water to100% Total ethanol 20%

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Abstract

The present invention is directed to the use of an agent selected from ethyl alcohol, isopropyl alcohol or a mixture thereof and a topically acceptable polymeric carrier in the preparation of a composition for the treatment of burns.

Description

FIELD OF THE INVENTION [0001] This invention relates to compositions comprising ethanol and / or isopropanol and a suitable carrier for the treatment of burns. BACKGROUND OF THE INVENTION [0002] Thermal burn injury induces non-specific inflammatory reaction generating dermal vascular damage, destruction of epidermis, edema and blister formation. These responses lead to progressive ischemic damage to the skin tissue, reduced blood perfusion and tissue necrosis. Since not all the skin tissues are immediately destroyed after thermal burn, depth of burns progresses with time. Cytokines IL6, IL1, TNF alpha, other pro-inflammatory interleukins and globulins are important factors in the development of microvascular injury and wound development in burned skin and tissue. Numerous attempts to favorably alter the burn wound by pharmacologic agent are generally of moderate efficiency. Burned skin could be a result of infliction produced by heat, light, UV rays, X-rays, Laser, Infrared rays, fric...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/14A61K31/045A61K8/34A61K8/81A61K9/00A61K31/78A61K47/02A61K47/10A61K47/32A61Q19/00
CPCA61K9/0014A61K31/045A61K47/10A61K47/02A61K31/78A61P17/02
Inventor TOUITOU, ELKA
Owner YISSUM RES DEV CO OF THE HEBREWUNIVERSITY OF JERUSALEM LTD
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