16 results about "Rheumatologic Disorder" patented technology

The invention belongs to the technical field of medical instruments, and discloses an artificial intelligence-based rheumatism image auxiliary diagnosis device, which comprises a developing box and a base, a stretching structure is arranged in the developing box, and a lifting device is arranged at the bottom of the developing box. Through meshing transmission of the gear and the tooth groove and sliding fit of the T-shaped strip and the T-shaped groove, stable movement of the extension box is achieved, and the light guide piece can be flexibly unfolded and folded to adjust the display area; the reset spring assists in rolling the light guide sheet, and operation is efficient and convenient; the magnifying lens can adjust the horizontal position along the sliding groove through the sliding block, the angle is adjusted in combination with the universal support with damping, medical staff can conveniently and accurately observe details of rheumatism images, and the accuracy of auxiliary diagnosis is improved. And through cooperation of the rotating cylinder, the threaded rod and the telescopic rod, the height of the device is flexibly adjusted, the device can adapt to users of different heights, the operation comfort is improved, and actual application and operation are facilitated.

The present invention relates to an inhibitor of CD74 protein activity or expression, for the therapeutic use thereof in the prevention and / or treatment of chronic inflammatory diseases including: chronic inflammatory rheumatisms, chronic inflammatory dermatoses, chronic inflammatory bowel diseases and chronic inflammatory neurological diseases. In another embodiment, the invention relates to an isolated anti-CD74 antibody or fragment thereof, comprising six CDRs having the sequences SEQ ID NO. 3, 4, 5, 11, 12, and 13.

This invention discloses a method for predicting the efficacy of rheumatoid arthritis treatment based on multimodal feature fusion, relating to the fields of artificial intelligence and medical information processing. This method, targeting rheumatoid arthritis patients, integrates ultrasound images, radiomics features, and clinical characteristics to predict the efficacy response of traditional slow-acting antirheumatic drugs (csDMARDs). Specifically, it includes: standardizing and enhancing ultrasound images; extracting image depth features using a pre-trained ResNet convolutional neural network as the backbone model; extracting and standardizing radiomics and clinical features, and fusing them with image depth features through a Cross-Attention mechanism; optimizing feature distribution using supervised contrastive learning (SupConLoss) to improve model discriminative ability; and finally outputting the treatment response category through a fully connected layer. This invention establishes a high-performance predictive model with promising clinical applications by integrating ultrasound images, radiomics, and clinical data.

To provide a chitosan derivative or a composition containing the same, suitable for use in humans or animals, especially in the fields of treatment, surgery and beauty.SOLUTION: The inventors set out to develop a chitosan having both good antioxidant properties and good mechanical properties (called biomechanical properties) for the intended applications in humans or animals. The present invention relates to a crosslinked carboxyalkyl chitosan forming a matrix, to a composition comprising it, to a process for preparing it and in particular to therapeutic, rheumatological, ophthalmological, cosmetological, plastic surgery, internalsurgery, dermatological, gynaecological or cosmetic. In particular, the present invention relates to a matrix comprising a carboxyalkyl chitosan having glucosamine units, N-acetylglucosamine units, and glucosamine units substituted with carboxyalkyl groups, wherein the carboxyalkyl chitosan has a degree of acetylation, expressed as moles of N-acetyl groups relative to moles of total glucosamine units, in the range of greater than 40% up to 80%, and wherein the carboxyalkyl chitosan is crosslinked by covalent bonds between the carboxyalkyl chitosan chains.SELECTED DRAWING: None

The invention relates to the technical field of pharmacy, in particular to biomimetic mineralized peptide-graphene bone joint health-care paste as well as a preparation system and a preparation method thereof. The health-care cream comprises an olibanum serratum resin extract, thyme flower / leaf oil and other extracts, hexanediol, p-hydroxyacetophenone, triethanolamine, chlorphenesin and a biomimetic mineralized peptide-graphene composite material. The graphene oxide layer is introduced into the bone joint health-care ointment, so that the conductivity of a medicine carrying system is improved, directional migration of calcium ions and phosphorus ions is promoted, and the mineralization process is accelerated; in addition, the bone targeting peptide is modified on the surface of the carrier, so that the traditional Chinese medicine extract, phosphorus ions and calcium ions are effectively and efficiently permeated into the bone joint part, and the bone joint treatment effect is improved. The health-care ointment can quickly resist inflammation, relieve pain, promote cartilage / bone repair and promote microcirculation, so that microcrack new sites are increased, continuous anti-inflammation is realized, and pain, stiffness and structural damage caused by gonitis, scapulohumeral periarthritis and rheumatism are remarkably improved.

The invention discloses traditional Chinese medicine moxibustion equipment for relieving rheumatism pain, and relates to the technical field of moxibustion. Comprising a bed body, a leg moxibustion assembly, an arm moxibustion assembly and a trunk moxibustion assembly. Arm supporting plates are arranged on the two sides of the bed body; the leg moxibustion assembly and the trunk moxibustion assembly are arranged on one side of the bed body in the length direction; the leg moxibustion assembly is used for conducting moxibustion on the legs of the patient, and the trunk moxibustion assembly is used for conducting moxibustion on the trunk of the patient; the two sets of arm moxibustion assemblies are arranged on the sides, in the length direction, of the two arm supporting plates correspondingly and used for conducting moxibustion on the arms of the patient. The bed type structure is adopted, the leg moxibustion assembly, the arm moxibustion assembly and the trunk moxibustion assembly are arranged, moxibustion can be conducted on the legs, the arms, the trunk and other parts of a patient at the same time, equipment replacement or repeated position adjustment is not needed, and the treatment efficiency is remarkably improved.

The invention discloses a novel RA (rheumatoid arthritis) marker long-chain non-coding RNA (ribonucleic acid) and application thereof in rheumatoid arthritis, and belongs to the field of molecular biology of rheumatism. The new RA marker long-chain non-coding RNA, namely LINC00837, can promote the proliferation and migration of rheumatoid arthritis fibroblast-like synovial cells and the secretion of anti-inflammatory factors, so that the RA marker long-chain non-coding RNA can be used as a diagnostic preparation and a therapeutic preparation for rheumatoid arthritis. According to the sequence of the long-chain non-coding RNA, specific real-time quantitative PCR primers and probes are designed and synthesized, and a preparation for auxiliary diagnosis or curative effect prediction of RA is prepared. A real-time quantitative PCR preparation is utilized to detect the expression level of the long-chain non-coding RNA in an RA clinical case specimen, the expression of the long-chain non-coding RNA in the RA is obviously up-regulated, and the long-chain non-coding RNA is expected to be prepared into a preparation for auxiliary diagnosis or curative effect prediction of the RA.

The invention discloses an application of a combination of circular RNA and targeted ETS-1 as a rheumatoid arthritis marker. The nucleotide sequence of the circular RNAcirc-CBLB is SEQ ID NO. 1, and the nucleotide sequence of the circular RNAcirc-CBLB is SEQ ID NO. The nucleotide sequence of the target ETS-1 is shown as SEQ ID NO. 2. The combination of the circular RNAcirc-CBLB and the targeted ETS-1 can be used as a marker for diagnosing RA, can evaluate RA inflammation and disease activity degree, and proves that the circular RNAcirc-CBLB and the targeted ETS-1 can be used for treating inflammation-related rheumatism.

Inventive name: A traditional Chinese medicine composition with the functions of clearing heat and removing dampness, promoting blood circulation to remove blood stasis, and dredging collaterals to relieve pain Technical field: A traditional Chinese medicine composition for treating rheumatoid arthritis with damp-heat and obstruction of collaterals Technical problem: The composition can treat rheumatoid arthritis with damp-heat and obstruction of collaterals, and the symptoms include red and swollen joints, pain like burning, morning stiffness, limited activity, accompanied by aversion to wind and fever, sweat without relief, irritability, thirst, dry stool and red urine, red tongue, yellow or dry fur, and slippery and rapid pulse. Solution: The composition is prepared from honeysuckle, atractylodes, atractylodes rhizome, giant knotweed, cuscuta, angelica, white peony root, milkvetch root, sago palm seed, centipede, nitraria, and licorice in a specific weight ratio. Main use: The composition can treat rheumatoid arthritis with damp-heat and obstruction of collaterals.

Rheumatoid arthritis (RA) is the most common form of inflammatory rheumatism, affecting small joints, where swelling and pain reside, accompanied by structural damage that can lead to functional disability if no treatment is offered. The present inventors have shown that circulating MAIT cells are reduced and exhibit an activated and anti-apoptotic phenotype in rheumatoid arthritis patients compared with healthy controls. MAIT cell levels were also found to be increased in synovial fluid compared with peripheral blood, suggesting that the deficiency of circulating MAIT cells is due to migration of MAIT cells into joints. The severity of arthritis induced by methylated bovine serum albumin was reduced in mice from which MAIT cells had been ablated. This data suggests that MAIT cells are responsible for the exacerbation of arthritis. Thus, the present invention relates to the use of agents capable of inhibiting MAIT cell activation for the treatment of rheumatoid arthritis.

The invention provides a composition for treating rheumatism, rheumatoid, red and swollen joints, fracture and hyperostosis and a preparation method and application thereof.The composition is prepared from, by weight, 3-100 parts of lycopodium clavatum, 5-90 parts of garden balsam stems, 5-80 parts of unprocessed radix aconiti, 5-70 parts of unprocessed radix aconiti kusnezoffii, 3-100 parts of unprocessed frankincense, 5-70 parts of myrrh, 3-65 parts of cortex acanthopanacis, 5-70 parts of cortex erythrinae and 10-80 parts of asarum. The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 6-75 parts of cassia twig, 5-80 parts of yam rhizome, 10-90 parts of radix stephaniae tetrandrae, 5-100 parts of rheum officinale, 5-85 parts of fructus gardeniae, 5-89 parts of sappan wood, 3-75 parts of radix salviae miltiorrhizae, 3-100 parts of semen brassicae, 5-75 parts of pinellia ternate, 5-100 parts of pepper, 5-90 parts of pawpaw, 5-85 parts of radix clematidis, 3-100 parts of erodium stephanianum willd and 6-90 parts of herba siegesbeckiae. The composition disclosed by the invention can take effect quickly, has good effects of promoting blood circulation to remove blood stasis, promoting qi circulation to relieve pain, eliminating arthralgia and removing stasis, has a good curative effect on rheumatism, rheumatoid, red and swollen joints and hyperostosis, and is free of stimulation, short in application / application time, remarkable in curative effect and free of relapse. And the bone healing speed of a fracture patient is obviously promoted.

Rheumatoid arthritis (RA) is the most common form of inflammatory rheumatism involving small joints which are the seat for swelling and pain with structural damage, responsible for functional disabilities if no treatment is proposed. The inventors show that circulating MAIT cells were reduced and exhibited an activated and anti-apoptotic phenotype in RA patients compared to healthy controls. MAIT cell levels were also found to be increased in the synovial fluid as compared with the peripheral blood, suggesting that circulating MAIT cell deficiency is due to the migration of MAIT cells into the joint. Severity of arthritis induced by mBSA was reduced in mice depleted in MAIT cells. This data suggest that MAIT cells contribute to exacerbation of arthritis. Thus the present invention relates to the use of an agent capable of inhibiting the activation of MAIT cells for the treatment of rheumatoid arthritis

The invention provides an application of circular RNA (Ribonucleic Acid) in rheumatism related to inflammatory response of cells, and belongs to the field of molecular biology of rheumatism. The hascirc0005732 can regulate and control a p38MAPK pathway, inhibit formation of neutrophil outer traps, block crosstalk between neutrophil and synovial cells, and inhibit and regulate cell proliferation and inflammatory response. On the basis of new CircRNA-hascirc005732 found by a whole transcriptome high-throughput sequencing technology, the invention proves that circ0005732 can effectively regulate phosphorylation activation of a p38MAPK signal channel, inhibit neutrophil from releasing extracellular traps, and down-regulate expression of inflammatory factors and proliferation of synovial cells, so that the application of CircRNA-hascirc005732 is developed. Therefore, the method is proved to be used as a treatment strategy for developing the rheumatoid arthritis related to the targeted cell inflammatory response.

The invention discloses application of ubiquitination modification of protein in rheumatism related to cell inflammatory response and hypercoagulable state, and belongs to the technical field of rheumatism molecular biology. Ubiquitin-binding enzyme UBE2A is highly expressed in RA patients, and an NF-kappa B signal channel is activated by mediating ubiquitination modification of NEMO, so that inflammatory response and hypercoagulable state are promoted. Bioinformatics analysis, machine learning screening, a cell co-culture model and clinical sample verification are comprehensively utilized to prove that UBE2A is a key molecule in the RA pathogenesis process, and it is prompted that UBE2A can be used as a new target for RA diagnosis / treatment. Therefore, UBE2A and related pathways thereof can be used for preparing medicines for treating rheumatoid arthritis, especially for regulating inflammation and abnormal blood coagulation.

The utility model belongs to the field of traditional Chinese medicine fumigation, and provides a portable traditional Chinese medicine fumigation device, which comprises a main body shell used for carrying traditional Chinese medicine fumigation; the fumigation mechanism is fixedly arranged at the top of the main body shell; the control mechanism is fixedly arranged at the bottom of the main body shell; the medicine carrying mechanism is fixedly arranged in the main body shell; the heating mechanism is fixedly arranged in the main body shell and located below the medicine carrying mechanism; different modes are changed through a mode knob, the traditional Chinese medicine fumigation physiotherapy mode can be conveniently adjusted according to the requirements of a patient, the specific pertinence is high, joint swelling and pain caused by rheumatism can be subjected to fumigation physiotherapy by selecting different traditional Chinese medicines, stomach cold, abdominal distension and the like in digestive diseases can be treated, meanwhile, the medicine carrying chamber is arranged to be detachable, and the traditional Chinese medicine fumigation physiotherapy device is convenient to use. The transparent design is adopted, liquid medicine replacement and residual medicine amount observation are facilitated, and the whole device is small in overall size, convenient to carry and capable of being used anytime and anywhere in travel and home life.