The invention discloses an aero-engine service life prediction method based on label-free, unbalanced and initial value uncertain data, which comprises the following steps of firstly, carrying out feature screening on an engine training data set by utilizing a correlation index and a trend index; then, obtaining a health state label through quantum fuzzy clustering, training a multivariable deep forest classifier, and obtaining an aero-engine health assessment model; meanwhile, training a long-short cycle memory neural network (LSTM) time sequence prediction model by utilizing the engine training data set; and finally, obtaining the maintenance time and the final residual service life (RUL) of the engine at different health stages by using the engine test data set according to the trainedhealth assessment model and the time sequence prediction model. According to the method, the defects of no label, imbalance and initial value uncertainty of observation data are overcome, and a technical reference is provided for maintenance decisions of the aero-engine in different subsequent health stages.