Cytotropic heterogeneous molecular lipids (CHML), method of preparation, and methods of treating patients with multiple cancers

Abstract

Cytotropic Heterogeneous Molecular Lipids (CHML) are used to treat patients with multiple cancers. Numerous studies have been conducted in cellular, animal, pre-clinical and clinical trials. Results showed that CHML, as a biological molecular missile, can easily penetrate through the target cancerous cells to perform programmed cancer cell death (cancer apoptosis). Furthermore, CHML has produced anti-cancer angiogenesis and induced immune function increase. CHML was used to treat 592 patients with cancers in clinical trials. Results confirmed the following advantages of CHML treatment: non-toxicity, high response rate, high quality of life, and high survival rate for these patients. The protocols include local injection, arterial drip and intravenous drip to treat cancers of liver, lung, skin, breast, brain glioma, colon and rectum, stomach, head and neck, leukemia, malignant lymphoma, sarcoma, malignant melanoma, myeloma, and metastasis cancers, etc.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] The present application claims priority under 35 USC 119(e) to U.S. Provisional Patent Application No. 60 / 835,446 filed on Aug. 4, 2006 the entire contents of which are hereby incorporated by reference.BACKGROUND OF THE INVENTION [0002] 1. Field of the Invention [0003] Cytotropic Heterogeneous Molecular Lipids (CHML) penetrate through target cancerous cells to perform programmed cancer cell death (cancer apoptosis). Furthermore, CHML has produced anti-cancer angiogenesis and induced immune function increase. [0004] 2. Description of the Related Art [0005] Phosphatide has been known to form small multilayered capsules while dispersing in water, and discovered that each layer of bimolecular lipids in a multilayer cyst is separated by water, the thickness of each layer being about 40 Å. This kind of capsule formed of microparticles, having a structure similar to a biomembrane, is termed a liposome. [0006] Since liposomes form a hydrophilic...

AI Technical Summary

Benefits of technology

"The invention is about a new technology called Cytotropic Heterogeneous Molecular Lipids (CHML) that can be used to treat cancer. CHML has been found to have several advantages over existing liposome technology, including being non-toxic, effective in treating various types of cancer, and having a high survival rate for patients. CHML has also been shown to induce programmed cancer cell death (apoptosis) and has been found to be safe in clinical studies. The patent text explains the technical effects of CHML and its potential use in treating cancer."

Problems solved by technology

Although cholesterol is useful for regulating the flowability and permeability of a bimolecular layer, cholesterol is not healthy for human beings.

However, the chemical properties of phosphatide with unsaturated fatty acid chain, such as of lecithin and soya bean lecithin, are prone to displaying insufficient stability.

Phosphatide is susceptible to oxidation and hydrolysis.

Thus leakage of drugs will be promoted so that retaining of drugs will become less and the liposome will be easily aggregated and precipitated, thereby producing toxicity.

In the preparation of liposomes, it is a difficult problem to envelope a large quantity of drug.

Also, when the molecule of the drug is small and easily subject to percolation, the envelopment quantity of the drug will be weaker.

As a result, conventional art liposome technology has been found to lack sufficient stability to deliver substances associated with rigorous therapeutic regimens.

Chemotherapeutic drugs are intended to destroy cancer cells, but are largely non-selective in their eradication of the body's cells.