Compositions including antibiotics and methods for using same

Abstract

Compositions including a quinolone component, such as ofloxacin, having fungistatic activity in the compositions, present in an amount effective as an antibiotic when the composition is placed in a mammalian eye, a NSAID component present in an amount to reduce inflammation or pain when the composition is placed in the eye, and a carrier component in an amount effective to act as a carrier for the quinolone component and NSAID component are provided. Methods of using the present compositions, for example, to resolve microbial infections and / or to reduce inflammation and / or pain in a mammalian eye are included within the scope of the present invention. Methods for treating corneal injuries are also included. In addition, methods for treating ocular infections, for example, corneal infections, are included.

Description

RELATED APPLICATION [0001] This application is a continuation-in-part of co-pending U.S. patent application Ser. No. 10 / 236,712, filed Sep. 6, 2002, which is a continuation of U.S. patent application Ser. No. 09 / 624,129, filed Jul. 14, 2000, which is a continuation-in-part of U.S. patent application Ser. No. 09 / 364,334 filed Jul. 30, 1999, and U.S. patent application Ser. No. 09 / 365,291, filed Jul. 30, 1999, the disclosure of each of which is hereby incorporated in its entirety herein by reference.BACKGROUND OF THE INVENTION [0002] The present invention relates to compositions including antibiotics and to methods for using such compositions. More particularly, the invention relates to compositions including antibiotics which have added protection against fungal contamination, which reduce inflammation or pain and / or which are useful in the treatment of corneal ulcers. [0003] Various antibiotic components have been used in ocular applications, for example, to control or manage or pre...

AI Technical Summary

Benefits of technology

The present invention provides new antibiotic compositions for use in mammalian eyes, particularly humans, to prevent, control or manage ocular microbial infections, reduce inflammation and pain, and prevent corneal injuries. The compositions include a quinolone component, an NSAID component, and a carrier component. The quinolone component has antifungal and bacteriocidal properties, while the NSAID component reduces inflammation and pain. The compositions are effective, safe, and can be used in single or multiple dose forms. The use of these compositions provides therapeutic benefits to humans or animals with ocular infections or injuries.

Problems solved by technology

Antibiotic compositions, even with preservatives, have been susceptible to microbial, for example, fungal, contamination.

In addition, preservatives tend to cause irritation, allergic reactions, and / or other detrimental side effects when the preserved composition is administered to a patient.

Corneal injuries, such as corneal ulcers and other corneal conditions which are infected or if left untreated are likely to become infected, are quite painful and sometimes require lengthy periods of time to heal.

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