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Surgical hydrogel

a technology of hydrogel and hydrogel gel, which is applied in the direction of drug compositions, peptide/protein ingredients, extracellular fluid disorder, etc., can solve the problems of fibrinous exudate release, frequent and unfortunate adhesion formation, and serious complications, so as to prevent adhesion formation and facilitate wound healing. , the effect of affecting the haemostasis

Inactive Publication Date: 2010-11-18
MEDTRONIC XOMED INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0022]Hydrogels of the invention assist in wound healing and may help prevent adhesions forming between neighbouring tissues that have been damaged so as to make them susceptible to adhesion formation. Hydrogels of the invention may also affect haemostasis by reducing or stopping bleeding of a wound. The hydrogels are biodegradable under surgical conditions and will break down gradually over a period of days or weeks.
[0091]In another aspect the invention provides a use of a hydrogel of the invention in the manufacture of a medicament for reducing or stopping bleeding of a wound.

Problems solved by technology

The formation of adhesions is a frequent and unfortunate result of many surgeries.
Trauma to the tissue caused by handling and drying during surgery causes a fibrinous exudate to be released.
The formation of adhesions can lead to serious complications such as small bowel obstruction, female infertility and chronic pain.
Unfortunately, current procedures for reducing adhesions and / or achieving hemostasis are not particularly effective and can be unpleasant for the patient.
In addition, in some circumstances treatments aimed at hemostasis may increase the risk of adhesion formation.
However, removal of the nasal packs can cause mucosal trauma which increases the likelihood that adhesions will form.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

N-Succinyl Chitosan Polymer

DMF Method

[0282]Batch A. Succinic anhydride (2.15 g, 0.0215 mol) was added to chitosan (1.5 g, 0.007 mol) in 100 ml N,N-dimethylformamide (DMF). The mixture was heated to 150° C. under nitrogen for 3 hrs.

[0283]On cooling the solid was collected from the mixture and washed with methanol then acetone. The dried solid was dissolved in sodium hydroxide (400 ml, 2M) and the solution stirred overnight. Not all of the solid dissolved. The undissolved solid was filtered and the solution evaporated to about 30-50 ml.

[0284]The solution was dialysed in a 3 L beaker by dialysis bag for 48-60 hours with the water changed periodically. The solution was then concentrated and freeze-dried. The N-succinyl-chitosan product was obtained as a cotton-like solid.

[0285]Batch B. Chitosan (from squid pens) (30 g) and succinic anhydride (42 g) in DMF (500 ml) was heated to 140° C. for 20 hrs. The resulting N-succinyl chitosan was recovered by filtration and washed with ethanol and ...

example 2

Aldehyde-Derivatised Dextran

[0289]Batch A. Dextran (1 g, MW 60,000-90,000) was dissolved in 20 ml distilled water. Sodium periodate (2 g) was added to the solution which was stirred for 3 hours at room temperature. The solution was dialysed in a 3 L beaker overnight with the water changed periodically. The solution was then concentrated and freeze-dried to give aldehyde-derivatised dextran as a white powder.

[0290]Batch B. Dextran (20 g, Aldrich, Mn 21,500, MW 142,000) was dissolved in water (200 ml) and then added to a stirring mixture of sodium periodate (40 g in 200 ml). The temperature of the exothermic reaction was kept at below 35° C. by external cooling and the reaction was performed under nitrogen. After 3 hr, the solution was dialyzed for 3 days (water changed every 12 hr), filtered and lyophilized to give aldehyde-derivatised dextran as a white powder (14.7 g, found C, 39.8%; H, 5.9%). The final molecular weight was Mn 2570, MW 4700.

[0291]Batch C. Dextran (36 g, Aldrich foo...

example 3

Polymer Network Comprising N-Succinyl Chitosan Cross-Linked with Aldehyde-Derivatised Dextran Polymer in Aqueous Solution

[0292]N-succinyl chitosan from Example 1 (30 mg) was dissolved in 0.6 ml distilled water to make a 5% w / v aqueous solution (Solution A). Aldehyde-derivatized dextran polymer (30 mg) was dissolved in 0.6 ml distilled water to make a 5% w / v aqueous solution (Solution B).

[0293]Solution A and Solution B were mixed together until a hydrogel formed (approximately 2 minutes). The hydrogel is the polymer network comprising N-succinyl-chitosan cross-linked with aldehyde-derivatised dextran polymer in aqueous solution.

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Abstract

The invention provides a hydrogel suitable for use in wound healing, particularly for reducing post-surgical adhesions. The hydrogel comprises cross-linked derivatives of chitosan and dextran polymers. The hydrogel forms when solutions of the polymers are combined.

Description

BACKGROUND OF THE INVENTION[0001]The formation of adhesions is a frequent and unfortunate result of many surgeries. Adhesions are fibrous bands connecting tissue surfaces that are normally separated. Adhesions are particularly common following abdominal and pelvic surgeries such as hernia repair, gynaecological surgeries and colorectal surgeries.[0002]Trauma to the tissue caused by handling and drying during surgery causes a fibrinous exudate to be released. If the exudate is not absorbed or lysed, it may collect in the peritoneal or pelvic cavity where it is converted into an adhesion. The exudate becomes ingrown with fibroblasts, collogen is deposited and blood vessels begin to form, allowing organisation of the adhesion.[0003]The formation of adhesions can lead to serious complications such as small bowel obstruction, female infertility and chronic pain. Patients may need to undergo further surgery to dissect adhesions, with no guarantees that new adhesions will not form.[0004]Te...

Claims

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Application Information

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IPC IPC(8): A61K38/43A61K38/17A61K38/18A61K31/56C08B37/08A61P17/02A61P41/00
CPCA61L26/0052A61L26/008A61L31/041A61L31/145A61L2400/04C08B37/0063A61K45/06A61K31/738C08L5/08A61P17/02A61P41/00A61P9/06A61K47/50A61K31/721A61K31/722
Inventor ATHANASIADIS, THEODOREHANTON, LYALL ROBERTMORATTI, STEPHEN CARLROBINSON, BRIAN HARFORDROBINSON, SIMON RAESHI, ZHENGSIMPSON, JAMESWORMALD, PETER JOHN
Owner MEDTRONIC XOMED INC
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