Live microbial microbicides

a microorganism and live technology, applied in the field of live microbial microorganism microorganism microorganismicides, can solve the problems of no widely available biomedical intervention, no effective vaccine development, and little success in trying to slow the spread of hiv by behavioral measures
US20130209407A1Inactive Publication Date: 2013-08-15UNITED STATES OF AMERICA
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
UNITED STATES OF AMERICA
Publication Date
2013-08-15
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention relates, e.g., to a commensal bacterium which can colonize the genitourinary and / or gastrointestinal mucosa, and which, under suitable conditions, secretes a heterologous antimicrobial polypeptide, wherein the secreted antimicrobial polypeptide is effective to inhibit infectivity by, or a pathogenic activity of, a pathogen. In a most preferred embodiment, the antimicrobial polypeptide inhibits HIV infection (e.g., fusion) and / or pathogenesis. Also described are preventive or therapeutic compositions comprising the commensal bacteria, and methods to inhibit infectivity and / or pathogenesis, using the bacteria.
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Description

[0001] This application is a Continuation-In-Part of PCT application, PCT / US2005 / 030216, filed Aug. 25, 2005, and claims the benefit of the filing date of U.S. provisional applications, Ser. No. 60 / 604,051, filed Aug. 25, 2004 and 60 / 688,376, filed Jun. 8, 2005, both of which are incorporated herein in their entirety.FIELD OF THE INVENTION

[0002] The present invention relates, e.g., to a commensal bacterium that can colonize the mucosa of the gastrointestinal and / or genitourinary tract and, under suitable conditions, can block the infectious and / or disease-causing activity of a pathogen by secreting a heterologous antimicrobial polypeptide. Also described are preventive and therapeutic compositions comprising such bacteria, and methods to inhibit a pathogen, comprising administering such a bacterium to a subject in need of such treatment.BACKGROUND INFORMATION

[0003] The global HIV / AIDS epidemic continues to grow at an alarming rate. There are now more than 40 million people infected wit...

Claims

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