Microbial fermentation for the production of terpenes

a technology of terpenes and fermentation, which is applied in the direction of transferases, lyases, carbon-carbon lyases, etc., can solve the problems of not all bacteria comprise the necessary cellular machinery to produce terpenes and/or their precursors, and most bacteria are not known to produce any terpenes, etc., and achieve the effect of increasing the number of copies
US20150191747A1Inactive Publication Date: 2015-07-09LANZATECH NZ INC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
LANZATECH NZ INC
Publication Date
2015-07-09
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a method for producing a terpene or a precursor thereof by microbial fermentation. Typically, the method involves culturing a recombinant bacterium in the presence of a gaseous substrate whereby the bacterium produces a terpene or a precursor thereof, such as mevalonic acid, isopentenyl pyrophosphate, dimethylallyl pyrophosphate, isoprene, geranyl pyrophosphate, farnesyl pyrophosphate, and / or farnesene. The bacterium may comprise one or more exogenous enzymes, such as enzymes in mevalonate, DXS, or terpene biosynthesis pathways.
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Description

CROSS REFERENCE TO RELATED APPLICATIONS

[0001] This application is a continuation of U.S. patent application Ser. No. 13 / 909,012 filed Jun. 3, 2013, which claims the benefit of U.S. Provisional Patent Application 61 / 654,412 filed Jun. 1, 2012, the entirety of which are incorporated herein by reference.SEQUENCE LISTING

[0002] This application includes a nucleotide / amino acid sequence listing submitted concurrently herewith and identified as follows: 278,490 byte ASCII (text) file named “LT079US2_ST25.txt” created on Mar. 5, 2015 the entirety of which is incorporated herein by reference.FIELD OF THE INVENTION

[0003] The present invention relates to recombinant microorganisms and methods for the production of terpenes and / or precursors thereof by microbial fermentation of a substrate comprising CO.BACKGROUND OF THE INVENTION

[0004] Terpenes are a diverse class of naturally occurring chemicals composed of five-carbon isoprene units. Terpene derivatives include terpenoids (also known as isopreno...

Claims

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