HERIPENES WITH PAIN-RELIEVING EFFECT, ACTIVE SUBSTANCES OF Hericium erinaceus MYCELIUM AND THE PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE HERIPENES OR ACTIVE SUBSTANCES

a technology of hericium erinaceus and active substances, which is applied in the field of active substances with pain-relieving effects, can solve the problems of few effective drugs that thoroughly inhibit pain, difficult treatment, tolerance and dependence problems,
US20170312247A1Inactive Publication Date: 2017-11-02GRAPE KING
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
GRAPE KING
Publication Date
2017-11-02
Estimated Expiration
Not applicable · inactive patent

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Abstract

The present invention is related to an active substance of Hericium erinaceus having a pain-relieving effect, and a pharmaceutical composition including the active substance. The active substance is prepared using the following steps: (a) inoculating a mycelium of H. erinaceus on an agar plate and incubating at 15-32° C. for 8-16 days; (b) inoculating the incubated H. erinaceus mycelia from step (a) into a medium in a flask and incubating at 20-30° C. and pH 4.5-6.5 for 3-5 days; (c) inoculating the incubated H. erinaceus mycelia from step (b) into a medium in a fermentation tank and incubating at 24-32° C. and pH 4.5-5.5 for 8-16 days to obtain a fermented medium of the H. erinaceus mycelia; and (d) desiccating the fermented medium of the H. erinaceus mycelia from step (c) to obtain the powder of the H. erinaceus mycelia, which is further purified and isolated to obtain a novel compound of H. erinaceus.
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Description

FIELD OF THE INVENTION

[0001] The present invention is related to an active substance with a pain-relieving effect, in particular, an active substance originated from Hericium erinaceus. BACKGROUND OF THE INVENTION

[0002] The neural transduction pathway of nociception and the P2-purinoceptor (P2R)

[0003] The generation of nociception involves the transduction of pain signals on a series of neural pathways, finally arriving at the cerebrum, so that a human body feels pain. The neural transduction pathway of nociception starts from the generation of stimulation, followed by transforming this stimulation into neurosignals by nociceptors. The neurosignals are transmitted to the dorsal root ganglion (DRG), followed by transmission to the spinal cord and finally arrive at the nociception area in the thalamus of the cerebrum. In the preceding research, it is indicated that the distribution of the P2-purinoceptors (P2Rs) can be seen on a series of neural transduction pathways, e.g. the sensory ne...

Claims

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