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A pharmaceutical composition for reducing local fat and uses thereof

a technology of local fat and composition, which is applied in the direction of drug compositions, plant/algae/fungi/lichens ingredients, and metabolic disorders, etc., can solve the problems of common weight loss regimens, inability to reduce fat at a specific location, severe damage to nerves, blood vessels, and other tissues, so as to reduce localized fat, reduce localized fat, and reduce fat

Pending Publication Date: 2018-08-30
CALIWAY BIOPHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention provides a pharmaceutical composition for reducing localized fat that can be used without surgery or equipment. The composition contains drug-containing micelles made of surfactants and resveratrol encapsulated in the micelles. The composition can reduce fat at the injection site and has advantages of high stability, high fat tissue bioavailability, and minimal side effects. The invention promotes apoptosis of adipocytes, achieving significant fat reduction with minimal inflammation and necrosis. The pharmaceutical composition can be injected subcutaneously or applied through cream or patch application. The invention can be used on areas like the waist, abdomen, legs, arms, chin, or face.

Problems solved by technology

Furthermore, common weight loss regimens, whether it is through diet or exercise, cannot reduce fat at a specific location.
However, the procedure of liposuction causes severe damages to the nerves, blood vessels, and other tissues.
Liposuction also comes with risks of infections, severe bleeding, prolonged anesthesia, and unpredictable life-threatening conditions such as fat embolism and allergic reactions to anesthesia.
In addition, it is common to experience significant bruising and swelling, severe pain, and post-operational recovery can take as long as 3 to 6 months, and the liposuction site may become uneven.
Although some non-surgical localized fat-reducing pharmaceutical compositions or equipments can partially lower the side effects, they are usually not effective and come with other side effects, such as necrosis of surrounding normal cells, inflammation of surrounding tissues, and sharp pain.
Additionally, their administration sites are limited.

Method used

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  • A pharmaceutical composition for reducing local fat and uses thereof
  • A pharmaceutical composition for reducing local fat and uses thereof
  • A pharmaceutical composition for reducing local fat and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment 1

of a Resveratrol Subcutaneous Injection and a Green Tea Extract Subcutaneous Injection on the Subcutaneous Fat and Body Weight of Rats

[0209]Preparation of a green tea extract solution for subcutaneous injection: a 5 mg / mL green tea extract aqueous solution was prepared with water for injection and green tea extract. The green tea extract aqueous solution was filtered through a 0.2 μm filter to obtain the 5 mg / mL green tea extract solution for subcutaneous injection in the present experiment. The green tea extract solution for subcutaneous injection had to be stored in dark at 4° C.

[0210]Preparation of a resveratrol solution for subcutaneous injection: a 5 mg / mL resveratrol solution was prepared with polysorbate 80 (tween 80), which is an excipient commonly used by prior arts for non-hydrophilic drug formulations for injection, ethanol, water for injection, and resveratrol. The detailed preparation method is as follows: 0.5 g of resveratrol was mixed with an appropriate amount of eth...

experiment 2

of Different Kinds of Resveratrol Subcutaneous Injection Formulation on the Subcutaneous Fat and Body Weight of Rats

[0220]Resveratrol normal saline solution, resveratrol PEG solution, and resveratrol ELP solution were prepared as follows:

[0221]Preparation of the Resveratrol Normal Saline Solution:[0222]500 mg of resveratrol was mixed with an appropriate amount of normal saline for injection to make the total volume become 100 mL. The solution was stirred well to completely dissolve resveratrol to obtain the resveratrol normal saline solution. The concentration of resveratrol in said resveratrol normal saline solution was 5 mg / mL.

[0223]Preparation of the Resveratrol PEG Solution.[0224]15 g of polyethylene glycol 400 (abbreviated as PEG 400) and 15 g of glycerol were mixed with an appropriate amount of normal saline for injection to make the total volume become 100 mL. The solution was stirred well to completely dissolve PEG 400 and glycerol to obtain a PEG-glycerol mixture. 450 mg of...

experiment 3

of Resveratrol Simple Composition Subcutaneous Injection Formulation comprising Micelles on the amount of Subcutaneous Fat and Body Weight of Fats

[0238]Resveratrol ELP partial micellar formulation, resveratrol HS-15 partial micellar formulation, resveratrol ELP micellar formulation, and resveratrol HS-15 micellar formulation were prepared as follows:

[0239]Preparation of the resveratrol ELP partial micellar formulation: 20 g of Kolliphor ELP (also known as Cremophor ELP, abbreviated as ELP) was mixed with an appropriate amount of normal saline for injection to make the total weight become 100 g. The solution was stirred well to completely dissolve Kolliphor ELP (also known as ELP) to obtain a 20% ELP solution. 400 mg of resveratrol was mixed with an appropriate amount of the 20% ELP solution to make the total weight become 80 g. The solution was stirred well to completely dissolve resveratrol to obtain the resveratrol ELP partial micellar formulation. In said resveratrol ELP partial ...

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Abstract

The present invention provides a pharmaceutical composition for reducing localized fat, comprising a pharmaceutically acceptable aqueous solution, drug-containing micelles made of surfactants, and resveratrol encapsulated in said drug-containing micelles. This pharmaceutical composition for reducing localized fat can reduce the fat at the administration site, and has the advantages of high stability, high fat tissue bioavailability, few side effects, and sustained release.

Description

FIELD OF THE INVENTION[0001]The present invention relates to a pharmaceutical composition for reducing localized fat, specifically, relates to a pharmaceutical composition comprising drug-containing micelles and resveratrol encapsulated in the micelles, and the pharmaceutical composition is for localized fat reduction.BACKGROUND OF THE INVENTION[0002]In recent years, more and more people have changed their views of beauty and raised their standards of individual health and body shape. As a result, people are not only concerned about weight loss, but focus more on reducing localized fat or contouring body shape in order to be healthier and achieve better body shape. Furthermore, common weight loss regimens, whether it is through diet or exercise, cannot reduce fat at a specific location. Currently, if wanting to reduce localized fat at specific locations (such as the waist, abdomen, legs, arms, chin, and face, etc), the only available technology is liposuction.[0003]At present, lipos...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/107A61K47/44A61K31/05A61K9/08A61K36/82
CPCA61K9/107A61K47/44A61K31/05A61K9/08A61K36/82A61K8/347A61Q19/06A61K8/86A61K8/11A61P43/00A61K9/0019A61K9/1075A61K31/12A61K45/06A61K2300/00A61K47/10A61K9/5015A61K36/9066A61K47/26A61K9/50A61K31/353A61K47/12A61P3/04
Inventor LING, YU-FANG
Owner CALIWAY BIOPHARM
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