Plant extract-based biologically active supplement having antibacterial, antiviral and antifungal action

Abstract

The present invention relates to a biologically active supplement formulated in an oral dosage form comprising nutraceutically effective amounts of an extract of Usnea barbata lichen, three-lobe beggarticks herb and common barberry berries and having an over-cumulative antibacterial, including bactericidal, action against the wide range of pathogens and conditional human pathogens, as well as over-cumulative antifungal action, including fungistatic and fungicidal actions. In addition, the supplement can comprise black elder berry extract, Baikal skullcap root extract, and fermented black garlic powder.The biologically active supplement of the invention can be used for enhancement of the general non-specific resistance of the body and for prevention or adjuvant therapy of the wide range of bacterial and fungal infections.

Description

FIELD OF THE INVENTION[0001]The invention relates to the field of chemical, pharmaceutical and food industries, in particular to a biologically active supplement having a wide spectrum of antibacterial, antiviral and antifungal, including fungicidal, action encompassing many bacterial, viral and fungal pathogens important for humans, the supplement comprising a combination of plant extracts.BACKGROUND[0002]One of the important directions in the development of new agents designed to affect bacterial, viral and fungal pathogens and conditional pathogens of importance in medicine is creating the new biologically active supplements, which currently represent an important alternative to traditionally used drugs.[0003]In creating the new formulations of biologically active supplements having antibacterial, antiviral and antifungal action, it is advantageous to use the medicinal plant potential and to identify new types of activity not previously studied in already known medicinal plants. ...

AI Technical Summary

Benefits of technology

[0022]These problems have been solved within the present invention by creating the biologically active supplement comprising a combination of extracts of Usnea barbata lichen, three-lobe beggarticks herb, common barberry berries, black elderberry, Baikal skullcap and optionally black garlic. The technical result of the claimed invention consists firstly in expanding the range of biologically active supplements increasing the overall non-specific resistance of the body, having antibacterial, antiviral and antifungal action, and secondly in achieving an over-cumulative (synergistic) action, in particular antibacterial (bacteriostatic and bactericidal) and antifungal (fungistatic and fungicidal) effect against the wide range of pathogens and conditional pathogens of importance in medicine, and in expanding the spectrum of said biologically active supplement action.

[0023]The object and the result are achieved within the present invention by creating a biologically active supplement formulated in an oral dosage form of an antibacterial and antifungal action comprising nutraceutically effective amounts of common barberry berry extract, three-lobe beggarticks herb extract, Usnea barbata lichen extract, black elderberry berry extract, Baikal skullcap extract and optionally black garlic combined with nutraceutically acceptable excipients. The present biologically active supplement within the context of the present invention is shown to be active against the wide range of human pathogens and conditional pathogens including Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Salmonella enteritidis, Pseudomonas aeruginosa, Enterococcus faecalis, Acinetobacter baumannii, Streptococcus pneumoniae, Streptococcus pyogenes, Haemophylus influenzae, Streptococcus agalactiae, Enterobacter cloacae, Candida albicans, influenza A and B viruses and rhinoviruses, the supplement administration providing over-cumulative antibacterial (bacteriostatic and bactericidal) and over-cumulative antifungal (fungistatic and fungicidal) effects as well as antiviral effect preferably against influenza A and B viruses and against rhinoviruses. Within the present invention, the antiviral effect is achieved by including black elderberry berry extract and Baikal skullcap root extract into the composition of said biologically active supplement. This allows using the biologically active supplement of the invention for increasing the overall non-specific resistance of the recipient body and for prevention and adjuvant therapy of said infections.

Problems solved by technology

Further, Ghareeb A., Abeer E. et al., 2013 doesn't contemplate a possibility of enhancing the antibacterial and / or antifungal properties of barberry berry extract by combining thereof with other antibacterial or antifungal active plant extracts.

However, Zahra Dashti et al., 2014 and Ghareeb A., Abeer E. et al., 2013 do not contemplate a possibility of potentiating the antibacterial or antifungal action of barberry berry extract or expanding the spectrum of antibacterial or antifungal action of barberry berry extract by combining thereof with other plant extracts.

This problem is especially important due to the common usage of antibiotics promoting the development of antibiotic-resistant strains of pathogenic and opportunistic microorganisms.

Finally, as discussed, the prior art has not been able to provide a fungicidal effect using plant monoextracts of three-lobe beggarticks herb, common barberry berries, Usnea barbata, black elderberry berries, Baikal skullcap roots or combinations thereof, therefore there is still a need to create a plant extract-based biologically active supplement that would have a fungicidal action and could be used for prevention or complex therapy against candida infections.