Compositions comprising streptococcus pneumoniae polysaccharide-protein conjugates and methods of use thereof

a technology of streptococcus pneumoniae and conjugates, which is applied in the field of multivalent immunogenic compositions, can solve the problems of limited serotype coverage of prevnar® in certain regions of the world, infants and young children's poor response to unconjugated pneumococcal polysaccharides,
US20220296695A1Inactive Publication Date: 2022-09-22MERCK SHARP & DOHME LLC
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Patent Information

Authority / Receiving Office
US · United States
Patent Type
Applications(United States)
Current Assignee / Owner
MERCK SHARP & DOHME LLC
Publication Date
2022-09-22
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention is related to multivalent immunogenic compositions comprising more than one S. pneumoniae polysaccharide protein conjugates, wherein each of the conjugates comprises a polysaccharide from an S. pneumoniae serotype conjugated to a carrier protein, wherein the serotypes of S. pneumoniae are as defined herein. In some embodiments, at least one of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. In further embodiments, each of the polysaccharide protein conjugates is formed by a conjugation reaction comprising an aprotic solvent. Also provided are methods for inducing a protective immune response in a human patient comprising administering the multivalent immunogenic compositions of the invention to the patient. The multivalent immunogenic compositions are useful for providing protection against S. pneumoniae infection and / or pneumococcal diseases caused by S. pneumoniae. The compositions of the invention are also useful as part of treatment regimes that provide complementary protection for patients that have been vaccinated with a multivalent vaccine indicated for the prevention of pneumococcal disease.
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Description

FIELD OF THE INVENTION

[0001] The present invention provides multivalent immunogenic compositions having distinct polysaccharide-protein conjugates. Each conjugate consists of a capsular polysaccharide prepared from a different serotype of Streptococcus pneumoniae conjugated to a carrier protein, preferably CRM197. The immunogenic compositions provide broad coverage against pneumococcal disease.

[0002] The instant application contains a Sequence Listing which has been submitted electronically in ASCII format and is hereby incorporated by reference in its entirety. Said ASCII copy, created on Dec. 3, 2019, is named 24683WOPCT-SEQTXT-03DEC2019 and is 6 kilobytes in size.BACKGROUND OF THE INVENTION

[0003] Streptococcus pneumoniae is a Gram-positive bacterium and the most common cause of invasive bacterial disease (such as pneumonia, bacteraemia, meningitis and Otitis media) in infants and young children. Pneumococcus is encapsulated with a chemically linked polysaccharide which confers serot...

Claims

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