Drug delivery device for providing local analgesia, local anesthesia or nerve blockage

Abstract

The invention relates to a drug delivery device for providing local analgesia, local anesthesia or nerve blockade at a site in a human or animal in need thereof, the device comprising a fibrillar collagen matrix; and at least one drug substance selected from the group consisting of amino amide anesthetics, amino ester anesthetics and mixtures thereof, the at least one drug substance being substantially homogeneously dispersed in the collagen matrix, and the at least one drug substance being present in an amount sufficient to provide a duration of local analgesia, local anesthesia or nerve blockade which lasts for at least about one day after administration.

Description

INTRODUCTION[0001]This application is a continuation-in-part of U.S. Ser. No. 11 / 692,337 filed Mar. 28, 2007 now abandoned, which is herein incorporated by reference in its entirety.FIELD OF THE INVENTION[0002]The present invention relates to a drug delivery device for providing local analgesia, local anesthesia or nerve blockade and a method for providing local analgesia, local anesthesia or nerve blockade in a human or animal in need thereof.RELATED BACKGROUND ART[0003]Post-surgical pain is a complex response to tissue trauma during surgery that stimulates hypersensitivity of the central nervous system. Post-operative pain increases the possibility of post-surgical complications, raises the cost of medical care and, most importantly, interferes with recovery and return to normal activities of daily living. Management of post-surgical pain is a basic patient right. When pain is controlled or removed, a patient is better able to participate in activities such as walking or eating, w...

AI Technical Summary

Benefits of technology

The present invention is a drug delivery device that can provide pain relief and anesthesia at a specific location in humans or animals for at least one day after being administered. The device consists of a fibrillar collagen matrix and a drug substance that is homogeneously dispersed in the collagen matrix. The drug substance can be a combination of different types of anesthetics. The device can also be made in a biodegradable form.

Problems solved by technology

Post-operative pain increases the possibility of post-surgical complications, raises the cost of medical care and, most importantly, interferes with recovery and return to normal activities of daily living.

However, it is unclear whether differences in surgical procedure or whether visceral components influence efficacy.

However, in spite of widespread use, wound infiltration is still inconsistently and randomly used by many surgeons and anesthetists.

Although there is a great number of papers and reviews on this topic, there is little consensus available on when and after which surgical procedures, incisional local anesthesia may provide clinically relevant post-operative pain alleviation.

Although the majority of studies showed significant differences in at least one pain measure, several were of questionable clinical importance and the authors were surprised that local anesthesia was not associated with more consistent positive results.

However, such continuous infusion devices use much higher total doses of bupivacaine (between 2.5 mg / hr and 50 mg / hr with a maximum dosing duration of 5 and 2 days, respectively) and of course are less convenient than a biodegradable implant.

The in-dwelling catheter used in the pain pump system can lead to infection and must be removed by a physician or nurse.

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