34 results about "Insulin used" patented technology

An insulin pump for use in conjunction with a mobile communication terminal capable of measuring a blood glucose level, and a network for transmitting control information for the insulin pump are disclosed. The insulin pump includes an external input port, an output port, memory, a key input unit, a control unit, and a motor driver. The external input port receives information on the amounts of insulin to be injected. The output port outputs information on the amounts of insulin injected. The memory stores the information on the amounts of insulin injected. The key input unit inputs the status of a user. The control unit extracts the information on the amounts of insulin to be injected from the memory. The motor drive operates a soft motor to supply insulin.

Described and illustrated is a system for management of diabetes that includes an infusion pump, glucose sensor and controller with a method programmed in the controller. The infusion pump is configured to deliver insulin. The glucose sensor senses glucose levels in the subject and provide output signals representative of the glucose levels in the subject. The controller is programmed receives signals from at least one of the glucose sensor and the pump and configured to issue signals to the pump to deliver an amount of insulin determined by a feedback controller that utilizes a model predictive control based on desired glucose levels, insulin amount delivered and measured glucose levels of the subject. The controller is also configured to deliver insulin using a tuning factor (R) for a model predictive controller in the microcontroller as a conservative setting otherwise the system maintains a current tuning factor (R) for the controller.

A closed loop system or semi-closed loop system for infusing insulin using sensor values applies a redundant sensor system as a fail-safe method against sensor failure. The redundant glucose sensors are used corroborate each other and a failing sensor is detected if the sensors no longer corroborate each other. The use of redundant sensors has the additional benefit of producing better sensor signals compared to the use of a single sensor.

Described and illustrated is a system for management of diabetes that includes an infusion pump, glucose sensor and controller with a method programmed into the controller. The infusion pump is configured to deliver insulin to a subject. The glucose sensor is configured to sense glucose levels in the subject and provide output signals representative of the glucose levels in the subject. The controller is programmed receives signals from at least one of the glucose sensor and the pump and configured to issue signals to the pump to deliver an amount of insulin determined by a feedback controller that utilizes a model predictive control of the subject based on desired glucose levels, insulin amount delivered and measured glucose levels of the subject. The controller is also configured to deliver insulin using a tuning factor based on either one of an omission index module or a calibration index module.

An insulin infusion set (30) for use with an inserter (40) is disclosed. The infusion set (30) includes an extension set (50). The extension set (50) includes a housing (70), a base (90) and a latching device (82). The base (90) houses a base septum (120) and an infusion cannula (42). The latching device (82) releasably attaches the housing (70) to the base. When the housing (70) is attached to the base (90), a part of the housing (70) extends into and opens the base septum (120).

A pharmaceutical formulation for absorption through oral mucosae comprising an effective amount of (a) a pharmaceutical agent in mixed micellar form, (b) at least one micelle-forming compound selected from the group comprising an alkali metal alkyl sulfate and a polyoxyethylene sorbitan monooleate, (c) a block copolymer of polyoxyethylene and polyoxypropylene, (d) at least one additional micelle-forming compound, and (e) a suitable solvent. The invention also provides a metered dose dispenser (aerosol or non-aerosol) containing the present formulation and a method of administering insulin using the metered dose dispenser comprising administering split doses of a formulation containing insulin before and after each meal.

The invention discloses an insulin-used syringe needle with an adjustable injecting depth. The insulin-used syringe needle comprises a needle seat, a steel needle is connected in the needle seat through a bonding agent, internal threads for connecting the external threads on the front end of an insulin pen are arranged in the needle seat, a limit ring is sleeved on the needle seat, the external threads are arranged on the outer surface of the needle seat, the internal threads are arranged in the limit ring, and the needle seat and the limit ring is connected via engagement of the outer threads. The insulin-used syringe needle has the main beneficial effects that the risk of injecting into a muscle layer by mistake due to over-deep needle insertion is effectively prevented, a patient can adjust the injecting depth according to the self situation of fatness and thinness, so as to select the injecting depth suitable for self, and the practicability is strong.

The present invention provides an insulin-specific assay and an assay reagent capable of sensitively and specifically assaying insulin using an antibody having a property of reacting with insulin bound to an anti-insulin antibody while not reacting with insulin not bound to an anti-insulin antibody, without being affected by proinsulin and insulin analogs.

An insulin pump data acquisition device & system including: an insulin pump data acquisition device for use with an insulin pump, the data acquisition device including a holster having a wall defining an interior volume and an exterior volume, the exterior volume being sized to removably secure the insulin pump; an environmental sensor operable to generate environmental data in response to environmental conditions; memory operably connected to the environmental sensor, the memory being operable to store the environmental data; a controller operably connected to the environmental sensor and the memory, the controller being operable to control reading of the environmental data from the environmental sensor and writing of the environmental data to the memory; and a battery operably connected to power the environmental sensor, the memory, and the controller. The environmental sensor, the memory, the controller, and the battery are disposed within the interior volume.

The present invention refers to a method for producing a human insulin analogue with high efficiency and excellent yield, by means of a biotechnological process comprising transformation of a Pichia pastoris yeast strain. In particular, the invention refers to a biotechnological process for obtaining aspart insulin.

The present invention relates to human insulin expression plasmids and a method for producing insulin using the same. The plasmids comprise a sequence encoding a compound of the formula R—B—X-A, in which R is a leader peptide of the formula of Met-Thr-Met-Ile-Thr-Y (SEQ ID NO: 36), in which Y is one selected from lysine, arginine, a peptide containing lysine as an amino acid at its C-terminal, or a peptide containing arginine as an amino acid at its C-terminal; B is human insulin B-chain or analogue thereof; X is a peptide connecting B with A; and A is human insulin A-chain or analogue thereof. The method for preparing insulin using the plasmids according to the present invention converts the proinsulin fusion protein into human insulin in a single enzymatic cleavage process and minimizes the generation of by-products after the enzymatic cleavage, thereby producing insulin at a high yield. Therefore, the plasmids according to the present invention and the method for preparing insulin using the same can be usefully applied to the industrial mass-production of human insulin.

The invention discloses ginsenoside-insulin nano gel as well as a preparation method and application thereof. A hypoglycemic drug insulin used as a drug effect ingredient is combined with ginsenosidegel nano-particles having an effect of reducing blood sugar, so that the ginsenoside-insulin nano gel having double blood sugar reduction effects is prepared. By using the ginsenoside gel nano-particles, slow-release transdermal drug administration of insulin can be realized, and a side effect caused by injecting the insulin is avoided. The ginsenoside-insulin nano gel disclosed by the invention is used for preparing a transdermal drug administration preparation and has the characteristics of quick transdermal absorption rate, security, stability, no pain, convenience and the like; moreover, the preparation method has the advantages of simpleness, low production cost, and easiness for amplification.

The invention discloses an application of a traditional Chinese medicine composition in the preparation of medicines for preparing diabetic ketoacidosis complicated with leukemoid reaction. The traditional Chinese medicine composition comprises herbal medicines such as ginseng, rhizoma polygonati, rhizoma atractylodis, radix sophorae flavescentis, poria cocos, dwarf lilyturf tuber, prepared fleeceflower root, rehmannia root, dogwood, coptidis rhizoma and fortune eupatorium herb. The traditional Chinese medicine composition is mainly used for tonifying qi and yin, strengthening spleen and transferring body fluid, and has the effects of clearing away heat, eliminating dampness and promoting blood circulation to remove meridian obstruction. After the traditional Chinese medicine composition is taken, the dosage of insulin used by patients is gradually reduced, the blood glucose control is normal and stable, the time of urine acetone bodies turning to negative is obviously shortened, and the state of illness can be controlled as soon as possible.

The present application discloses the preparation of peptides, including insulin and insulin derivatives, using efficient methods for solid-phase and solution phase peptide synthesis.

The invention relates to the field of insulin injection pumps, in particular to an insulin pump suitable for all-weather use.The insulin pump suitable for all-weather use comprises a medicine storage device and a control system, a semiconductor refrigeration device and a temperature sensor are arranged in the medicine storage device, the temperature sensor outputs temperature data in the medicine storage device to the control system, and the control system outputs a work instruction to the semiconductor refrigeration device.Through coordination of the semiconductor refrigeration device and the temperature sensor, the insulin pump suitable for all-weather use solves the problem that a diabetic patient uses an insulin pump to inject insulin at high temperature and is suitable for use in summer and hot regions.In terms of characteristics of the semiconductor refrigeration device, the size and the weight of the insulin pump cannot be increased obviously, and the insulin pump cannot produce noise during use and cannot bring inconvenience to users.