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39results about How to "More of in in localization" patented technology
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Activin-ActRIIa antagonists and uses for promoting bone growth
ActiveUS20070249022A1Increase in mineralizationReduce expressionPeptide/protein ingredientsAntibody mimetics/scaffoldsCancer researchAntagonist
In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density.
Owner:ACCELERON PHARMA INC
Use of GDF traps to increase red blood cell levels
ActiveUS20100068215A1Improve pharmacokineticsImprove purification effectPeptide/protein ingredientsAntibody mimetics/scaffoldsPrimateRed Cell
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Owner:ACCELERON PHARMA INC
Activin-ActRII antagonists and uses for increasing red blood cell levels
ActiveUS20090047281A1Easy to produceReduce expressionCompound screeningApoptosis detectionPrimateRed Cell
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Owner:ACCELERON PHARMA INC
Activin-actriia antagonists and uses for decreasing or inhibiting FSH secretion
ActiveUS20090118188A1Inhibit growthAvoid survivalHormone peptidesPeptide/protein ingredientsAndrologyPlant Germ Cells
In certain aspects, the present invention provides compositions and methods for decreasing FSH levels in a patient. The patient may, for example, be diagnosed with an FSH-related disorder or desire to delay or inhibit germ cell maturation.
Owner:ACCELERON PHARMA INC
Activin-actriia antagonists and uses for treating or preventing breast cancer
ActiveUS20090074768A1Inhibit growthAvoid survivalPeptide/protein ingredientsAntibody mimetics/scaffoldsGynecologyAntagonist
In certain aspects, the present invention provides compositions and methods for treating or preventing breast cancer in humans.
Owner:ACCELERON PHARMA INC
Activin-actriia antagonists and uses for promoting bone growth in cancer patients
ActiveUS20090142333A1Promote growthStimulates of mineralizationPeptide/protein ingredientsAntibody mimetics/scaffoldsIncreased Bone DensityBone growth
In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma.
Owner:ACCELERON PHARMA INC
Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators
ActiveUS8216997B2Increased formationImprove the level ofOrganic active ingredientsPeptide/protein ingredientsPrimatePhysiology
Owner:ACCELERON PHARMA INC
Activin-actrii antagonists and uses for increasing red blood cell levels
ActiveUS20090163417A1Reduce expressionIncrease redCompound screeningApoptosis detectionPrimateRed Cell
Owner:ACCELERON PHARMA INC
Method of increasing red blood cell levels or treating anemia in a patient
ActiveUS8058229B2Low affinityReduce impactPeptide/protein ingredientsAntibody mimetics/scaffoldsPrimateRed Cell
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Owner:ACCELERON PHARMA INC
Antagonists of activin-actriia and uses for increasing red blood cell levels
ActiveUS20100028331A1Easy to produceReduce expressionPeptide/protein ingredientsAntibody mimetics/scaffoldsPrimateRed Cell
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Owner:ACCELERON PHARMA INC
Activin-ActRIIa antagonists and uses for promoting bone growth
ActiveUS20090098113A1Reduce expressionPromote bone growthPeptide/protein ingredientsAntibody mimetics/scaffoldsIncreased Bone DensityBone growth
Owner:ACCELERON PHARMA INC
Activin-ActRIIa antagonists and uses for promoting bone growth
ActiveUS20090099086A1Reduce expressionPromote bone growthPeptide/protein ingredientsAntibody mimetics/scaffoldsIncreased Bone DensityCancer research
Owner:ACCELERON PHARMA INC
Antagonists of actriib and uses for increasing red blood cell levels
InactiveUS20100028332A1Distribution moreMany formatsPeptide/protein ingredientsAntibody mimetics/scaffoldsRed CellAntagonist
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Owner:ACCELERON PHARMA INC
Use of gdf traps to increase red blood cell levels
ActiveUS20120015877A1Distribution moreMany formatsPeptide/protein ingredientsAntibody mimetics/scaffoldsPrimateRed Cell
Owner:ACCELERON PHARMA INC
Methods for dosing an activin-actriia antagonist and monitoring of treated patients
InactiveUS20100015144A1Undesired effectImprove the level ofPeptide/protein ingredientsAntibody mimetics/scaffoldsHematologyAntagonist
Owner:ACCELERON PHARMA INC
Combined use of gdf traps and erythropoietin receptor activators to increase red blood cell levels
ActiveUS20110038831A1Increase formationHigh levelOrganic active ingredientsPeptide/protein ingredientsCellular levelRodent
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Owner:ACCELERON PHARMA INC
Actriib antagonists and dosing and uses thereof
InactiveUS20110070233A1Improve bone strengthIncrease bone densityOrganic active ingredientsPeptide/protein ingredientsIncreased Bone DensityBone growth
In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma. Methods for dosing a patient with an ActRIIb antagonist are also provided.
Owner:ACCELERON PHARMA INC
Methods for dosing an actriib antagonist and monitoring of treated patients
InactiveUS20100008918A1Increase red blood cellRaise hemoglobin levelsPeptide/protein ingredientsAntibody mimetics/scaffoldsAntagonistTreated patient
In certain aspects, the present invention provides methods for dosing a patient with an ActRIIb antagonist and methods for managing patients treated with an ActRIIb anatagonist. In certain aspects, the methods involve measuring one or more hematologic parameters in a patient.
Owner:ACCELERON PHARMA INC
Antagonists of activin-actriia and uses for increasing red blood cell levels
ActiveUS8895016B2Reduce expressionIncrease red blood cell and hemoglobin levelPeptide/protein ingredientsAntibody mimetics/scaffoldsPrimateRed blood cell
In certain aspects, the present invention provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans.
Owner:ACCELERON PHARMA INC
Antagonists of actriib and uses for increasing red blood cell levels
InactiveUS20120003218A1Distribution moreMany formatsHormone peptidesPeptide/protein ingredientsPrimateRed Cell
Owner:ACCELERON PHARMA INC
Method of promoting bone growth by an anti-activin B antibody
ActiveUS8128933B2Reduce expressionPromote bone growthHormone peptidesPeptide/protein ingredientsIncreased Bone DensityBone growth
Owner:ACCELERON PHARMA INC
Activin-ActRIIa antagonists and uses for decreasing or inhibiting FSH secretion
ActiveUS7960343B2Distribution moreMany formatsHormone peptidesPeptide/protein ingredientsGerm cellAntagonist
Owner:ACCELERON PHARMA INC
Activin-ActRIIa antagonists and uses for treating multiple myeloma
ActiveUS8173601B2Reduce expressionPromote bone growthPeptide/protein ingredientsAntibody mimetics/scaffoldsIncreased Bone DensityBone growth
Owner:ACCELERON PHARMA INC
Activin-actriia antagonists and uses for treating multiple myeloma
ActiveUS20130004489A1Reduce expressionPromote bone growthPeptide/protein ingredientsAntibody mimetics/scaffoldsIncreased Bone DensityBone growth
In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density, as well as for the treatment of multiple myeloma.
Owner:ACCELERON PHARMA INC
Activin-actriia antagonists and uses for treating or preventing breast cancer
ActiveUS9526759B2Improve targetingDistribution moreImpression capsPeptide/protein ingredientsGynecologyAntagonist
Owner:ACCELERON PHARMA INC
Serum amyloid p derivatives and their preparation and use
One aspect of the present invention relates to the surprising discovery that modification of a glycan structure on a human SAP polypeptide can increase the biological activity of the SAP polypeptide relative to a corresponding sample of wild-type SAP isolated from human serum. The disclosure provides both variant human SAP polypeptides and methods for making the same. In particular, the present invention provides methods and compositions for in vitro and in vivo addition, deletion, or modification of sugar residues to produce SAP polypeptides, such as a human SAP polypeptide, having a desired glycosylation pattern.
Owner:PROMEDIOR
BMP-ALK3 antagonists and uses for promoting bone growth
ActiveUS8338377B2Potent stimulatorsReduce expressionPeptide/protein ingredientsAntibody mimetics/scaffoldsIncreased Bone DensityBone growth
Owner:ACCELERON PHARMA INC
Methods for treating myelodysplastic syndromes and sideroblastic anemias
ActiveUS20160289286A1Increase productionIncreased erythropoiesisPeptide/protein ingredientsAntibody mimetics/scaffoldsPrimateRed blood cell
In certain aspects, the present disclosure provides compositions and methods for increasing red blood cell and / or hemoglobin levels in vertebrates, including rodents and primates, and particularly in humans. In some embodiments, the compositions of the disclosure may be used to treat or prevent sideroblastic anemias and myelodysplastic syndromes or one or more complications associated sideroblastic anemias and myelodysplastic syndromes.
Owner:ACCELERON PHARMA INC
Methods for treating myelodysplastic syndromes and sideroblastic anemias
ActiveUS10189882B2High selectivityRaise the ratioPeptide/protein ingredientsAntibody mimetics/scaffoldsPrimateRed blood cell
Owner:ACCELERON PHARMA INC
Bmp-alk3 antagonists and uses for promoting bone growth
ActiveUS20100266612A1Promote growthStimulates of mineralizationPeptide/protein ingredientsAntibody mimetics/scaffoldsIncreased Bone DensityBone growth
In certain aspects, the present invention provides compositions and methods for promoting bone growth and increasing bone density and strength. In certain embodiments, the present invention provides ALK3 polypeptides, including ALK3-Fc fusion proteins.
Owner:ACCELERON PHARMA INC
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