The invention discloses a bandwidth compression prediction method based on a quad-tree. The prediction method comprises the following steps of: step 1, dividing a macroblock to be predicted accordingto a quad-tree algorithm; step 2, acquiring a first bit number and a first prediction residual according to the macroblock to be predicted; step 3, acquiring a second bit number and a second prediction residual according to a first sub-macroblock, a second sub-macroblock, a third sub-macroblock, and a fourth sub-macroblock; step 4, determining whether to divide the macroblock to be predicted according to the first bit number, the first prediction residual, the second bit number, and the second prediction residual; and step 5, outputting the prediction residual and the minimum value of the pixel component of each divided sub-macroblock of the macroblock to be predicted. The bandwidth compression prediction method based on the quad-tree has good prediction effect and high processing efficiency, and can reduce the theoretical limit entropy when the method is used for complex texture image processing.