The invention provides a nitrogen dioxide concentration prediction method and system, belonging to the technical field of air quality monitoring, and obtains monitoring data such as air pollution monitoring data, meteorological monitoring data, remote sensing reanalysis meteorological field data and geographic covariate data; The forest model, the extreme gradient boosting tree model, and the gated recurrent unit neural network model combined with residual connection process the monitoring data respectively to obtain three predicted values of nitrogen dioxide concentration, and then combine with the weighted average algorithm to calculate the final nitrogen dioxide concentration. Nitrogen concentration value. The invention integrates multi-source spatiotemporal data, and learns the temporal and spatial variation patterns of nitrogen dioxide; through integrated learning combined with the advantages of different algorithms, the stability of the prediction results is improved, the prediction residual error is reduced, and the coverage is wide and the prediction is realized. High-precision, multi-time series nitrogen dioxide concentration prediction; ensures the portability of the machine learning prediction method, and can be directly applied to new monitoring stations with little historical data.