Oral drop pills with heat-clearing and detoxification function

A heat-clearing and detoxifying and preparation technology, which is applied in the direction of medical preparations containing active ingredients, pill delivery, antiviral agents, etc., can solve the problems of long dissolution time, inaccurate dosage, and low dissolution rate, so as to avoid gastrointestinal Tract irritation symptoms, enhanced bioavailability, accelerated dissolution and absorption

Inactive Publication Date: 2008-05-28
哈尔滨泰华药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent No. 98120420.1 discloses its granule dosage form, so far there is no drop pill dosage form to come out
[0003] Chinese patent medicine injection products are seriously lagging behind in production and basic research, and the standardization of medicines has not been resolved
So far, there is no effective quality control method that can comprehensively, comprehensively and truly reflect the quality of the product and its differences, and can effectively control the quality of the entire production process, resulting in unstable drug quality
At present, adverse reactions of traditional Chinese medicine injections occur from time to time, but it is impossible to find out which ingredients are caused by them fundamentally, so targeted aftermath treatment and remedial measures cannot be made in time, leaving hidden dangers for clinical medication in hospitals
In addition, the production and transportation costs of injection are high, and the use is inconvenient, which not only increases the economic burden of patients, but also increases the pain of application.
[0004] Due to preparation technology and other reasons, most oral preparations of drugs have problems such as long dissolution time, low dissolution rate, poor absorption, low intestinal first-pass effect, low bioavailability, and high production cost after taking, which affect the drug production. It also directly affects the treatment effect and increases the economic burden of patients.
However, the oral liquid also has the characteristics of low drug content, large dosage, inaccurate dosage, and inconvenient taking, and is also not easy to carry out.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0035] The preparation method of Qingrejiedu dripping pills of the present invention will be further described with the tests and results of several groups of specific examples.

[0036] Group 1: Tests with a single matrix

[0037] [Preparation experiment]

[0038] 1. According to the section [Preparation of Chinese medicine extract], first prepare the dry powder of the medicine extract for later use;

[0039] 2. Substrate - polyethylene glycol (2000、4000、6000、8000、10000、20000) , Polyoxyl 40 Stearate, Beta Cyclodextrin, Poloxamer, Sodium Carboxymethyl Starch, Sodium Lauryl Sulfate, Stearic Acid, Sodium Stearate, Glycerin Gelatin, Shellac with carrier;

[0040] 3. Proportion (in g or kg, in parts by weight)——drug extract: matrix=1:1~1:9;

[0041] 4. Then prepare according to the [preparation method], and various specifications of Qingrejiedu dripping pills can be prepared.

[0042] [test results]

[0043] Experiment 1: In order to observe the difference in quality of Qingre...

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PUM

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Abstract

The invention discloses a heat clearing and detoxicating dripping pill for treating influenza, meningitis, and common cold, which has the advantages of high biological availability, quick-speed medicine release, quick-speed effect, less toxic and side effects, no contamination in production, low cost of manufacture. The medicine is prepared through the conventional drop pill preparing process.

Description

technical field [0001] The invention relates to a pharmaceutical composition with heat-clearing and detoxifying effects, which is used for treating influenza, mild meningitis, and fever due to exogenous pathogenesis, in particular to an oral preparation of the pharmaceutical composition prepared based on the process of clearing away heat and detoxifying injection. Background technique [0002] Heat-toxic symptoms have different manifestations. Only by choosing appropriate medicines in a targeted manner and matching them properly can the characteristics of various medicines be brought into play and achieve synergistic and complementary effects. According to the ministerial drug standard WS 3 -The heat-clearing and detoxifying injection prepared according to the formula and extraction process given in B-3325-98 is made of honeysuckle, scutellaria, forsythia, gentian, gypsum, Anemarrhena, gardenia, isatis root, rehmannia, Radix Ophiopogon, Twelve pure traditional Chinese medic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/20A61K36/8968A61K36/8964A61K36/86A61K36/808A61K36/804A61K36/744A61K36/634A61K36/539A61K36/515A61K36/35A61K36/19A61K36/315A61K33/06A61P31/16A61P29/00
Inventor 曲韵智
Owner 哈尔滨泰华药业股份有限公司
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