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Water-base magnetic liquid and producing method thereof

A magnetic liquid and water-based technology, applied in magnetic liquid, radioactive carrier, gene therapy, etc., can solve the problems of large particle hydrodynamic diameter, low surface potential, low saturation magnetization, etc., and achieve good biocompatibility Effect

Inactive Publication Date: 2008-07-23
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the polysaccharide stabilizers currently used are dextran, chitosan, starch, etc., because there are only hydroxyl groups on the molecular chains of these polysaccharides, the force between them and the nanometer ferroferric oxide particles is small, and the modification effect Not ideal, the surface potential is low, the particle stability is poor, and the chemically active groups on the particle surface after modification are less, and the connection process with drugs, cells, proteins or genes is more complicated
In particular, the current preparation method makes this kind of water-based magnetic liquid have the disadvantages of too large particle hydrodynamic diameter, generally exceeding 300nm, thick outer coating layer, low saturation magnetization, or poor biocompatibility.

Method used

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  • Water-base magnetic liquid and producing method thereof
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  • Water-base magnetic liquid and producing method thereof

Examples

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Effect test

Embodiment 1

[0036] Take 9.6g FeCl 3 .6H 2 O, formulated into FeCl with a mass concentration of 60% 3 Solution, weigh 5g FeSO 4 .7H 2 O, made into FeSO with a mass concentration of 20% 4 Solution: The two solutions are mixed to form an iron salt mixed solution, and the molar ratio of ferrous sulfate: ferric chloride is 1:2. Dissolve 20g of sodium alginate with a weight average molecular weight of 20,000 in 100ml of 25wt% concentrated ammonia to form a sodium alginate ammonia mixed solution. At this time, the molar ratio of ammonia: ferric chloride is 40:1, and carboxypolysaccharide The mass ratio to ferroferric oxide is 5:1. The iron salt mixed solution and the sodium alginate ammonia mixed solution were mixed under stirring at 800 rpm, and then reacted under stirring for 40 minutes. The reaction temperature was stabilized at 90°C; after the reaction, the prepared water-based solution was centrifuged The ferroferric oxide magnetic liquid is centrifuged to remove the large precipitated particle...

Embodiment 2

[0038] Take 9.6g FeCl 3 .6H 2 O, formulated into FeCl with a mass concentration of 30% 3 Solution, weigh 5g FeSO 4 .7H 2 O, formulated into FeSO with a mass concentration of 15% 4 Solution, the rest of the steps are the same as in Example 1, 50ml of magnetic liquid with iron content of 3mg / ml can be obtained, and the saturation magnetization is about 0.5kA / m.

Embodiment 3

[0040] Take 9.6g FeCl 3 .6H 2 O, formulated into FeCl with a mass concentration of 45% 3 Solution, weigh 5g FeSO 4 .7H 2 O, formulated into FeSO with a mass concentration of 30% 4 Solution, the rest of the steps are the same as in Example 1, 30ml of the magnetic liquid with an iron content of 9mg / ml can be obtained, and the saturation magnetization is about 1.6kA / m.

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Abstract

A method for preparing water - based magnetic liquid includes using carboxyl polysaccharide as stabilizer of magnetic liquid, applying chemical coprecipitation process to form water - based magnetic liquid of magnetic iron oxide under stabilizer existence or applying chemical coprecipitation process to form nanoparticles of magnetic iron oxide first then carrying out surface modification to obtain water - based magnetic liquid of magnetic iron oxide.

Description

Technical field [0001] The invention relates to a water-based magnetic liquid and a preparation method thereof. technical background [0002] The so-called magnetic liquid refers to a stable colloidal system formed by highly dispersing nano magnetic particles with stabilizers in a carrier liquid. It is mainly composed of nano magnetic particles, stabilizer and carrier liquid. At present, water-based magnetic liquids can be divided into three categories according to the types of stabilizers used: 1. Use water-soluble organic small molecules such as amino acids, citric acid, folic acid, etc. as chelating agents and stabilizers; 2. Use surface The active agent forms a double-layer adsorption mode on the surface of the nanomagnetic particles to prepare the water-based magnetic liquid. The surfactants used include fatty acids, N-acyl amino acids, etc.; 3. The polymer with hydrophilic groups is used as the stabilizer, which is stable The main agents are polysaccharides, proteins, polya...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01F1/44A61K49/08A61K48/00A61K51/02
Inventor 徐雪青沈辉许家瑞
Owner SUN YAT SEN UNIV