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Preparation method of nano-grade rhenium sulfide colloid particle

A nano-colloid and colloidal particle technology, applied in chemical instruments and methods, inorganic chemistry, rhenium compounds, etc., can solve the problems affecting the penetration ability and large surface free energy of rhenium sulfide particles, and achieve easy particle size control and dispersibility. And the effect of good stability and simple operation

Inactive Publication Date: 2009-02-11
BEIJING UNIV OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the small size and large surface free energy of nanoparticles, nanoparticles are easily aggregated to form large particles and then precipitate. Therefore, macromolecules are usually added for dispersion protection during the preparation of nanoparticles. However, the surface of nanoparticles Macromolecules will increase the hydrodynamic particle size of the particles, so the usual method of dispersing nanoparticles will affect the penetration ability of rhenium sulfide particles in vivo

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Mix 11 mg of sodium perrhenate and 70 mg of sodium thiosulfate in 4 mL of ethylene glycol at 25 °C, add 100 μL of perchloric acid to the above solution, stir and react for 30 minutes to obtain a brown-black colloidal solution, adjust the colloidal The acidity of the solution reaches a pH value of 7, and distilled water is used to replace the ethylene glycol medium in the colloid by dialysis to obtain nano rhenium sulfide colloidal particles. Its average particle size is 5.5 nm; standard deviation is 1.9 nm.

Embodiment 2

[0022] Mix 11 mg of sodium perrhenate and 70 mg of sodium thiosulfate in 4 mL of propylene glycol at 15 ° C, add 200 μL of perchloric acid to the above solution, stir and react for 40 minutes to obtain a brown-black colloidal solution, adjust the concentration of the colloidal solution When the acidity reaches a pH value of 7, the ethylene glycol medium in the colloid is replaced by distilled water through dialysis to obtain nano rhenium sulfide colloidal particles. Its average particle size is 6.0 nm; standard deviation is 2.1 nm.

Embodiment 3

[0024] Mix 110 mg of sodium perrhenate and 700 mg of sodium thiosulfate in 4 mL of ethylene glycol at 25 °C, add 500 μL of perchloric acid to the above solution, stir and react for 50 minutes to obtain a brown-black colloidal solution, adjust the colloidal The acidity of the solution reaches a pH value of 6, and the ethanol is replaced by the ethylene glycol medium in the colloid by dialysis to obtain nanometer rhenium sulfide colloidal particles. Its average particle size is 5.0 nm; standard deviation is 1.8 nm.

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Abstract

The invention discloses a preparing method of nanometer grade rhenium sulfide colloid particle, which comprises the following steps: mixing tall-rhenate with hyposulfite evenly in multi-alcohol solvent; adding into perchloric acid or alcaine; reacting under normal temperature; preparing rhenium sulfide colloid; adjusting acidity of colloid; getting nanometer grade small size rhenium sulfide colloid particle with stable particle. This invention does not need add into protective agent and heat, which can be used to diagnose and cure tumor in medical domain.

Description

technical field [0001] The invention relates to a preparation method of nano-scale rhenium sulfide colloidal particles. Background technique [0002] Rhenium sulfide is used as a therapeutic radiopharmaceutical and has been applied in the field of nuclear medicine. There have been some studies on the preparation of rhenium sulfide particles, for example: Nucl.Med.Biol., 17, P 357-362, 1990 reported the preparation of Rhenium sulfide colloid, the method is to mix potassium perrhenate, sodium thiosulfate and hydrochloric acid in proportion, heat, add gelatin after separation and washing, and make colloid after crushing. This method is easy to form precipitation. [0003] Eur.J.Nucl.Med., 22(6), P 505-507, 1995, the above-mentioned method has been improved, that is, gelatin is added before the reaction, and finally adjusted to neutral colloid. [0004] Patent CN1237457 and patent CN1264601 use polyvinylpyrrolidone or gelatin as a dispersion protective agent to prepare a medica...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01G47/00
Inventor 涂伟霞
Owner BEIJING UNIV OF CHEM TECH
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