M-benzenedicarbonyl thioureas derivative, preparation and application thereof as fluorinion identification receptor

Abstract

The invention provides a kind of fluoride ion recognition acceptor isophthaloyl thiourea derivatives 3a, 3b, 3c and a phase transfer solvent-free grinding method preparation method thereof, which is to prepare isophthaloyl chloride and ammonium thiocyanate in a certain amount The proportion of the mixture was added to the mortar, and under the condition of phase transfer catalyst, the reaction was intermittently ground at room temperature for 5 to 7 hours to obtain isophthaloyl isothiocyanate; After 6 to 48 hours, a yellow or light yellow precipitate is obtained; filter, wash, and recrystallize with a mixed solvent of DMF-C2H5OH-H2O. The isophthaloylthiourea derivative receptors of the present invention have high recognition selectivity for fluoride ions: receptor 3a can use its obvious color change to identify fluoride ions with naked eyes; receptors 3a, 3b, and 3c can use Fluoride ion was identified by UV-Vis absorption spectrum and 1HNMR titration.

Description

technical field [0001] The invention relates to a class of isophthaloyl thiourea derivatives and a phase-transfer catalyzed solvent-free grinding preparation method of the derivatives, and also relates to the application of the derivatives as fluoride ion recognition acceptors. Background technique [0002] The interaction and mutual recognition between host and guest molecules, especially the interaction between host and guest with optical information response function, is one of the frontier topics in the field of supramolecular chemistry research. Molecular recognition is the process in which the subject selectively binds to the guest and produces a specific function. It is a necessary way to assemble high-level structures and the basis for studying the functions of assemblies. Anions play an important role in the metabolic process of organisms, and their transport inside and outside the cell membrane is completed under the control and recognition of corresponding binding...

AI Technical Summary

Problems solved by technology

Although the conventional solvent method has simple equipment and easy operation, there are defects such as solvent volatilization, waste and flammability in the reaction, which may easily cause environmental pollution and potential safety hazards.

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