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Preparation method for magnolol molecularly imprinted polymer film

A technology of molecular imprinting and polymer membranes, which is applied in the fields of alkali metal compounds, chemical instruments and methods, alkali metal oxides/hydroxides, etc., can solve the problems of high preparation process requirements, large amount of raw materials, and low imprinting efficiency. Achieve the effect of good separation effect, high reuse rate, and reduce preparation cost

Active Publication Date: 2014-01-29
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In previous applications, molecularly imprinted polymer membranes also have some disadvantages, such as a large amount of raw materials, high preparation process requirements, poor durability, and low imprinting efficiency.
There is no report on the preparation of molecularly imprinted polymer membranes by mechanochemical inclusion technology

Method used

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  • Preparation method for magnolol molecularly imprinted polymer film
  • Preparation method for magnolol molecularly imprinted polymer film
  • Preparation method for magnolol molecularly imprinted polymer film

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Put 0.20mmol of magnolol and 0.60mmol of HP-β-CD into a ball mill and mill for 60min to obtain the imprinted molecular clathrate, and mix it with 0.20mmol of methacrylamide, 0.80mmol of acrylic acid, and 5.00mmol of ethyl Diol dimethacrylate and 0.15 mmol of azobisisobutyronitrile were dissolved in 4.50 ml of tetrahydrofuran and 0.50 ml of dimethyl sulfoxide, ultrasonically degassed for 30.00 min, added 0.90 g of cellulose acetate, ultrasonically and Stir continuously for 4.00h to obtain a mixed solution. Soak a filter paper of a certain size in the mixture for about 6.00 minutes, take out the filter paper, sandwich it between two glass slides, place it in an oven and heat it for 3.00 hours of polymerization at a polymerization temperature of 60.00°C to obtain a polymer. The polymer was sonicated for 4.00 h with 40 ml of a mixed solution of methanol and acetic acid at a volume ratio of 9.00:1.00 to remove imprinted molecules, and then the acetic acid molecules were wash...

Embodiment 2

[0055] Put 0.20mmol of magnolol and 0.10mmol of β-CD into a ball mill and mill for 90 minutes to obtain the imprinted molecular clathrate, and mix it with 0.80mmol of methacrylamide and 3.00mmol of trimethoxypropane trimethyl Acrylate and 0.15 mmol of benzoyl peroxide were dissolved in 4.00 ml of tetrahydrofuran and 0.50 ml of dimethyl sulfoxide, ultrasonically degassed for 20.00 min, 0.50 g of cellulose acetate was added, and ultrasonically stirred continuously for 3.00 h to obtain Mixture. Soak a filter paper of a certain size in the mixture for about 6.00 minutes, take out the filter paper, sandwich it between two glass slides, place it in an oven and heat it for 4.00 hours of polymerization at a polymerization temperature of 50.00°C to obtain a polymer. The polymer was sonicated for 4.50 h with 40 ml of methanol and acetic acid mixed solution with a volume ratio of 8.00:1.00 to remove imprinted molecules, and then methanol was used to wash away acetic acid molecules. Fina...

Embodiment 3

[0057] Put 0.80mmol of magnolol and 0.80mmol of M-β-CD into a ball mill and mill for 40 minutes to obtain the imprinted molecular clathrate, and mix it with 0.90mmol of methacrylamide, 0.40mmol of acrylic acid, and 4.50mmol of pentaerythritol Dissolve triacrylate and 0.21 mmol of azobisisobutyronitrile in 5.00 ml of tetrahydrofuran and 0.50 ml of dimethyl sulfoxide, ultrasonically degas for 25.00 min, add 0.80 g of cellulose acetate, ultrasonically and continuously stir for 4.50 h , to obtain a mixture. Soak a filter paper of a certain size in the mixed solution for about 4.00min, take out the filter paper, clamp it between two glass slides, put it in an oven and heat it for polymerization for 3.50h at a polymerization temperature of 55.00°C to obtain a polymer. The polymer was sonicated for 8.00 h with 40 ml of a mixed solution of methanol and acetic acid at a volume ratio of 5.00:1.00 to remove imprinted molecules, and then the acetic acid molecules were washed away with met...

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Abstract

The invention discloses a preparation method for a magnolol molecularly imprinted polymer film. The preparation method includes the following concrete steps: both imprinted molecule magnolol and solid-phase reagent are put into a ball mill and ball-milled, so that imprinted molecule inclusion compound is obtained, and the inclusion compound, functional monomer, cross-linking agent and initiator are put into porogen, ultrasonically degasified, then added with bond and ultrasonically stirred, so that mixture is obtained; filter paper is immersed in the mixture, taken out, clamped between two glass sheets, put into an oven and heated to be polymerized, so that polymer is obtained; imprinted molecules are removed from the obtained polymer, and after washing and drying, the magnolol molecularly imprinted polymer film is obtained. The preparation method adopts the mechanochemical technology to include the imprinted molecules, so that the ability of the imprinted molecules in specific binding with the functional monomer is enhanced, as a result, the recognition selectivity of the finally prepared molecularly imprinted polymer film is greatly enhanced, and the magnolol separation effect is good.

Description

(1) Technical field [0001] The invention relates to a preparation method of a molecularly imprinted polymer film, in particular to a preparation method of a magnolol molecularly imprinted polymer film. (2) Background technology [0002] Magnolia officinalis is the dry bark, root bark or branch bark of Magnolia offcinalis Rend et Wils. or M. officinalis Rehd.et Wils.var.biloba Reht.et Wils. One of the traditional Chinese medicinal materials. Warm in nature, bitter in taste, non-toxic, enters the spleen, stomach, and large intestine meridians, and has significant effects of drying dampness and eliminating phlegm (Chinese herbal medicine, 2007, 30 (2), 237). In recent years, with the development of modern medicine, it has been found that in addition to the effects of eliminating chest and abdomen fullness, pain relief, invigorating the stomach, lowering qi and lowering adverse events, relieving cough, removing water poison, promoting blood circulation and removing blood stasis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08F222/14C08F220/06C08F220/56C08F212/34C08F212/36C08J9/26C08J5/18B01J20/26B01J20/28B01J20/30
Inventor 朱兴一王平谢捷苏为科
Owner ZHEJIANG UNIV OF TECH
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