Defervesce effervescence tablet for treating cold and preparation method thereof

A technology for antipyretic and effervescent tablets for colds is applied in the field of preparation of effervescent tablets of Chinese patent medicine, and can solve the problems of affecting curative effect, loss of effective ingredients, large dosage and the like

Active Publication Date: 2009-10-21
BEIJING ASIA EAST BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are some shortcomings in the original dosage forms. The disadvantage of the oral liquid is that the medicinal materials are boiled and alcoholized, and then the flavoring agent is added and filled. In the process, a lot of active ingredients are lost, which affects the curative effect
The disadvantage of granules is that they need to be taken with boiling water, the dissolution is often incomplete, and precipitation is easy to occur, and the dosage is large
The disadvantage of capsules is that they are generally not suitable for children and the elderly due to the inconvenience of swallowing

Method used

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  • Defervesce effervescence tablet for treating cold and preparation method thereof
  • Defervesce effervescence tablet for treating cold and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 1. Preparation of Ganmao antipyretic extract powder

[0032] (1) The proportioning ratio of raw materials is:

[0033] Daqingye 3400g Banlangen 3400g Forsythia 1700g Boxing Ginseng 1700g

[0034](2) Clean the above four herbs separately, remove impurities, and pass the inspection for later use: take Daqingye, Banlangen, Forsythia, and Quanshen and crush them into fine powder / crushed into coarse powder / cut into drinking pieces, add water to decoct twice , 2 hours each time, combine the decoction, filter, concentrate the filtrate to a relative density of about 1.10 (80-95°C), cool to room temperature, add 2 times the amount of ethanol to precipitate, let stand for 12 hours, and take the supernatant Concentrate the solution to a relative density of 1.20 (50-60°C), add 1 times the amount of water, stir, and let it stand for 8 hours, take the supernatant solution and concentrate it into a clear paste with a relative density of 1.10 (60-65°C), and dry it into Extract powder...

Embodiment 2

[0045] 1. Preparation of Cold and Antipyretic Extract Powder: Same as Example 1.

[0046] 2. Cold and antipyretic ring-shaped effervescent tablets (100 tablets)

[0047] Formula ratio:

[0048] Cold and antipyretic extract powder 105g tartaric acid 26g

[0049] Cyclamate 2g Flavor 1g

[0050] Potassium bicarbonate 32g PEG 4000 17g

[0051] Microcrystalline Cellulose 16g PVP 1g

[0052] 3. Preparation method

[0053] The cold and antipyretic extract powder obtained by spray drying is sealed and stored for later use; tartaric acid, sodium bicarbonate, and microcrystalline cellulose are respectively pulverized through a 100-mesh sieve, and sealed for later use; cyclamate and essence are pulverized through a 100-mesh sieve, and PEG 4000 is pulverized Pass through a 140-mesh sieve; control the ambient temperature of the formulation at 25°C and humidity below 45% during the preparation process; mix the cold-reducing fever extract powder with tartaric acid evenly according to th...

Embodiment 3

[0056] 1. Preparation of Cold and Antipyretic Extract Powder: Same as Example 1.

[0057] 2. Prepare cold and antipyretic ring-shaped effervescent tablets (100 tablets)

[0058] Formula ratio:

[0059] Cold Antipyretic Extract Powder 105g Malic Acid 30g

[0060] Acesulfame K 2g Fragrance 1g

[0061] Sodium bicarbonate 24g Potassium carbonate 8g

[0062] Cross-linked polyvinylpyrrolidone 20g Magnesium stearate 10g

[0063] 3. Preparation method

[0064] The cold and antipyretic extract powder obtained by spray drying is sealed and stored for later use; malic acid, sodium bicarbonate, potassium carbonate, and cross-linked polyvinylpyrrolidone are respectively pulverized through a 100-mesh sieve, and sealed and stored for later use; acesulfame potassium and essence are pulverized through 100 mesh Mesh sieve, magnesium stearate is crushed through a 140 mesh sieve; during the preparation process, the environmental temperature of the preparation is controlled at 25°C and the hu...

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Abstract

The invention relates to a defervesce effervescence tablet for treating cold and preparation process, wherein the medicament is prepared from clerodendroa cyrtophyllum, isatic root, capsule of weeping forsythia and bistort through specific processes. The tablet has the effects of heat clearing and detoxicating, and can be used for treating upper respiratory tract infection, acute tonsillitis laryngitis. The invention has the advantages of improved biological availability, easy oral administration, small amount of administration, and easiness in carrying. The selected auxiliary material and ring-shaped effervescent tablet can make the effervescent tablet disintegrate rapidly.

Description

technical field [0001] The invention relates to the technical field of a preparation method of a Chinese patent medicine effervescent tablet, in particular to a cold-reducing fever effervescent tablet and a preparation method thereof. Background technique [0002] At present, the main effervescent tablets in my country are health care products, such as vitamin C effervescent tablets, and some effervescent tablets for external gynecological medicine, such as Jieeryin effervescent tablets, metronidazole vaginal effervescent tablets, etc., but oral Chinese medicine Less effervescent preparations. And cold antipyretic prescription is made into the effervescent tablet of oral pure Chinese medicine preparation, has not been reported yet. In addition, annular tablets have been used in the food industry for a long time, but they are rarely used in the field of medicine, especially in the field of effervescent tablet preparation, which has not been reported yet. [0003] Traditional...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/46A61K9/20A61K36/704A61K36/634A61K36/315A61K36/19A61P29/00A61P31/00
Inventor 钟虹光罗晓健吕爱平周焘张国松曾志斌饶小勇
Owner BEIJING ASIA EAST BIO PHARMA CO LTD
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