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Calcium alginate gel bead with shell of porous calcium carbonate microsphere and its preparing method

A technology of calcium carbonate microspheres and calcium alginate, which is applied in the direction of pharmaceutical formulations, inorganic non-active ingredients, bulk transportation, etc., can solve the problems of affecting the use effect, easy to break, and the surface strength of gel beads is not high, and achieve good activity Substance adsorption performance, effect of improving surface strength

Inactive Publication Date: 2009-11-11
SOUTH CHINA UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The calcium alginate gel beads prepared by the above methods have a common disadvantage that the surface strength of the gel beads is not high, and they are easy to break, which affects its actual use effect.

Method used

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  • Calcium alginate gel bead with shell of porous calcium carbonate microsphere and its preparing method
  • Calcium alginate gel bead with shell of porous calcium carbonate microsphere and its preparing method
  • Calcium alginate gel bead with shell of porous calcium carbonate microsphere and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The porous calcium carbonate microspheres (see Fig. 1) of 40g 5 μm are uniformly dispersed in the sunflower oil of 4L, then 1L 1% sodium alginate aqueous solution is added dropwise in the mixed solution of porous calcium carbonate microspheres and sunflower oil, at 150rpm Stir for 10 min at a rotating speed of 10 min to form an emulsion. Add 100mL 200g / L gluconolactone aqueous solution dropwise to the emulsion, and continue to stir for 10 minutes. The prepared calcium alginate gel beads have a layer of porous calcium carbonate microspheres on the surface (see Figure 2), with regular appearance and high degree of sphericity. The particle size is between 100 μm and 1000 μm.

Embodiment 2

[0030] Evenly disperse 30g of 5 μm porous calcium carbonate microspheres in 4L of sunflower oil, then add 1L of 1% sodium alginate aqueous solution dropwise to the mixed solution of porous calcium carbonate microspheres and liquid paraffin, and stir at 150rpm for 10min. An emulsion is formed. Add 100mL 200g / L gluconolactone aqueous solution dropwise to the emulsion, and continue to stir for 10 minutes. The prepared calcium alginate gel beads have a layer of porous calcium carbonate microspheres on the surface. 1000μm.

Embodiment 3

[0032] Evenly disperse 50g of 1 μm porous calcium carbonate microspheres in 4L of sunflower oil, then add 1L of 1% sodium alginate aqueous solution dropwise to the mixture of porous calcium carbonate microspheres and decane, and stir at 150rpm for 10min. An emulsion is formed. Add 100mL 200g / L gluconolactone aqueous solution dropwise to the emulsion, and continue to stir for 10 minutes. The prepared calcium alginate gel beads have a layer of porous calcium carbonate microspheres on the surface. 1000μm.

[0033] In the foregoing examples, the coverage of the porous calcium carbonate microspheres on the surface shell of the prepared calcium alginate gel beads is regulated by the weight ratio of the porous calcium carbonate microspheres to the sodium alginate aqueous solution. Gel beads with different surface strengths and penetration rates need to be prepared.

[0034] As can be seen from the above, the present invention can improve the surface strength of the gel beads and im...

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Abstract

The invention relates to a method for preparing calcium alginate gel beads with porous calcium carbonate microspheres as the shell layer. The aqueous phase of sodium alginate is dispersed into the oil phase containing porous calcium carbonate microspheres, and then emulsified to form a water-in-oil emulsion. ; Porous calcium carbonate microspheres are adsorbed to the surface of the emulsion droplet to form a shell to stabilize the emulsion droplet; add gluconolactone aqueous solution to carry out gelation reaction of sodium alginate. The invention can simply and massively prepare microbeads with porous calcium carbonate microspheres as the shell and calcium alginate gel as the core.

Description

technical field [0001] The invention relates to a controlled-release carrier in the field of biomedicine, in particular to calcium alginate gel beads with porous calcium carbonate microspheres as shell layers and a preparation method thereof. Background technique [0002] Calcium alginate gel beads are currently commonly used cell and protein immobilization materials, especially the microcapsules formed by outer polymer material membranes (such as polylysine and chitosan) are used as immune isolation tools for cell transplantation and protein and protein. The controlled-release carrier of polypeptide biologically active substances has great application prospects in the field of biomedicine. Calcium alginate gel beads are prepared by cross-linking sodium alginate with calcium ions. Among the preparation methods of calcium alginate gel beads reported so far, the electrostatic method (Canadian patent No. 1241598) is to squeeze the sodium alginate solution through the needle an...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/36A61K47/02A61K9/00A61K9/16
Inventor 王朝阳刘红霞高权星童真
Owner SOUTH CHINA UNIV OF TECH