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Fixed dose compound preparation of antitubercular drug and its preparing method

A compound preparation and fixed-dose technology, applied in the field of medicine, to achieve the effects of reducing the number of pills taken, facilitating transportation and sales, and reducing risks

Active Publication Date: 2009-12-23
SHENYANG HONGQI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the treatment of tuberculosis has become a more important and challenging issue due to the drug resistance, especially multiple drug resistance (MDR) produced by conjugating bacilli

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Prescription 1:

[0054] Rifampicin 120.0g

[0055] Isoniazid 120.0g

[0056] Ethambutol Hydrochloride 250.0g

[0057] Low-substituted hydroxypropyl cellulose 74.2g

[0058] Microcrystalline Cellulose 141.1g

[0059] Sucrose fatty acid ester 37.1g

[0060] Opadry II 15g

[0061]

[0062] Made into 1000 pieces

[0063] Prescription 2:

[0064] Rifampicin 1200.0g

[0065] Isoniazid 1200.0g

[0066] Ethambutol hydrochloride 2500.0g

[0067] Low-substituted hydroxypropyl cellulose 742g

[0068] Microcrystalline Cellulose 1411g

[0069] Sucrose Fatty Acid Ester 371g

[0070] Opadry II 150g

[0071]

[0072] Made into 10000 pieces

[0073] Prescription 3:

[0074] Rifampicin 360.0g

[0075] Isoniazid 360.0g

[0076] Ethambutol Hydrochloride 750.0g

[0077] Low-substituted hydroxypropyl cellulose 222.6g

[0078] Microcrystalline Cellulose 423...

Embodiment 2

[0088] Tobacco tablets

[0089] Prescription 1:

[0090] Rifampicin 200.0g

[0091] Isoniazid 200.0g

[0092] Low-substituted hydroxypropyl cellulose 50.6g

[0093] Microcrystalline Cellulose 50.6g

[0094] Magnesium stearate 5.1g

[0095] Opadry II 10.0g

[0096]

[0097] Made into 1000 pieces

[0098] Prescription 2:

[0099] Rifampicin 2000g

[0100] Isoniazid 2000g

[0101] Low-substituted hydroxypropyl cellulose 506g

[0102] Microcrystalline Cellulose 506g

[0103] Magnesium Stearate 51g

[0104] Opadry II 100.0g

[0105]

[0106] Made into 10000 pieces

[0107] Prescription 3:

[0108] Rifampicin 200.0g

[0109] Isoniazid 200.0g

[0110] Low-substituted hydroxypropyl cellulose 50.6g

[0111] Microcrystalline Cellulose 50.6g

[0112] Magnesium stearate 5.1g

[0113] Opadry II 30.0g

[0114]

[0115]...

Embodiment 3

[0121] Ripinicotol Tablets

[0122] Prescription 1:

[0123] Rifampicin 1200.0g

[0124] Isoniazid 120.0g

[0125] Pyrazinamide 400.0g

[0126] Ethambutol Hydrochloride 250.0g

[0127] Low-substituted hydroxypropyl cellulose 115.2g

[0128] Sucrose Fatty Acid Ester 41.9g

[0129] Opadry II 21.0g

[0130]

[0131] Made into 1000 pieces

[0132] Prescription 2:

[0133] Rifampicin 1200.0g

[0134] Isoniazid 1200.0g

[0135] Pyrazinamide 4000.0g

[0136] Ethambutol hydrochloride 2500.0g

[0137] Low-substituted hydroxypropyl cellulose 1152.0g

[0138] Sucrose fatty acid ester 419.0g

[0139] Opadry II 210.0g

[0140]

[0141] Made into 10000 pieces

[0142] Prescription 3:

[0143] Rifampicin 360.0g

[0144] Isoniazid 360.0g

[0145] Pyrazinamide 1200.0g

[0146] Ethambutol Hydrochloride 750.0g

[0147] Low-substituted hydroxypropyl cellulose 345....

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PUM

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Abstract

The invention is a fixed-dose anti-tuberculosis drug compound preparation and a preparation method thereof, which has the characteristics of reducing the number of times of taking the medicine, reducing the occurrence of drug resistance, improving the curative effect of the medicine, and making the storage and transportation of the medicine more convenient. It is a fixed-dose compound preparation containing rifampicin, isoniazid, pyrazinamide and ethambutol hydrochloride, which also contains an appropriate amount of disintegrants, binders, lubricants, diluents and water-soluble packets. Clothing powder. First sieve rifampicin alone, pass through a 100 mesh sieve, and pass through a 60 mesh sieve, add binder, disintegrating agent and diluent, mix evenly, dry granulate, and then use disintegrating agent and diluent to mix with the above-mentioned The granules are mixed evenly and pressed into tablets to obtain the finished product. The invention is especially suitable for use by tuberculosis patients.

Description

Technical field: [0001] The present invention relates to the technical field of medicine, specifically, it relates to an anti-tuberculosis drug and its preparation process—a fixed-dose anti-tuberculosis drug compound preparation and a preparation method thereof. Background technique: [0002] Rifampicin is a broad-spectrum antibiotic, which has obvious antibacterial effect on most Gram-positive bacteria and many Gram-negative bacteria, and also has an effect on Chlamydia and viruses at high concentrations. In vitro and in vivo experiments have shown that rifampicin is effective against Mycobacterium tuberculosis, atypical mycobacteria and Mycobacterium leprae. This product has the strongest effect on Mycobacterium tuberculosis in the breeding period, and also has a bactericidal effect on Mycobacterium tuberculosis in the quiescent period, but the required concentration is about 10 times higher than that in the breeding period. The principle of antibacterial effect of rifamp...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61K31/4409A61K31/133A61K9/20A61K9/28A61P31/06
Inventor 何仲贵孙进张天虹孙继龙王卓
Owner SHENYANG HONGQI PHARMA
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