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Medicinal composition having cooperative action

A composition and technology of paeoniflorin, applied in the field of drug combination, can solve problems such as no scientific basis, no suggestion or attempt, etc.

Active Publication Date: 2009-12-23
YUNNAN BIOVALLEY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, the existing technology has not provided scientific basis for whether Erigeron breviscapine can be used in combination with Paeoniae officinalis and whether the mechanism of action of the two is additive, synergistic or antagonistic.
As for whether the two can be used in combination for other diseases (such as cardiovascular and cerebrovascular diseases, Alzheimer's disease), the prior art does not even have similar hints or attempts

Method used

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  • Medicinal composition having cooperative action
  • Medicinal composition having cooperative action
  • Medicinal composition having cooperative action

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0307] Embodiment 1 capsule

[0308] Take 10g of Erigeron breviscapus, crush it into a coarse powder, add 75% ethanol to reflux and extract three times, the first and second times each for 2 hours, and the third time for 1 hour, combine the extracts, concentrate under reduced pressure to about 400ml, and extract three times with n-butanol , 300ml each time, combine the n-butanol extract, concentrate under reduced pressure until there is no n-butanol smell, add 200ml of water, heat to dissolve, then dilute sodium hydroxide to adjust the pH value to 7, filter, and the filtrate is spray-dried to obtain the extract I standby;

[0309] Take 5g of Radix Paeoniae Rubra, crush it into a coarse powder, add 75% ethanol to reflux and extract three times, the first and second times each for 2 hours, and the third time for 1 hour, combine the extracts, concentrate under reduced pressure to about 400ml, and extract three times with n-butanol , 300ml each time, combine n-butanol extracts, c...

Embodiment 2

[0311] Example 2 tablet

[0312] Take one part of the extract I and two parts of the extract II of Example 1, add low-substituted hydroxypropyl cellulose, magnesium stearate, starch, and microcrystalline cellulose, and prepare 1000 grains according to the standard granulation and tableting process. After testing, it contains scutellarin 50mg / tablet, total caffeic acid ester 200mg, and paeoniflorin 100mg / tablet.

Embodiment 3

[0313] Embodiment 3 soft capsules

[0314] Get two parts of extract I and one part of extract II of Example 1, add starch and magnesium stearate, mix well, and make soft capsules according to the standard process. After testing, each capsule contains 100mg of scutellarin, 500mg of total caffeic acid ester and 50mg of paeoniflorin.

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PUM

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Abstract

The invention relates to a composition for medicinal or functional health care products, a preparation method and application thereof. The composition contains natural plant extracts or monomers as active ingredients. The pharmaceutical composition of the present invention can be used for treating and preventing diabetes and its complications, senile dementia, cardiovascular and cerebrovascular diseases, brain cell protection, central retinal vein occlusion, hyperlipidemia, fatty liver, and for preventing cardiovascular and cerebrovascular diseases recurrence and prevention of restenosis after angioplasty.

Description

technical field [0001] The present invention relates to a drug combination, specifically, a medicinal or functional health product composition containing natural plant extracts or monomers, used for the treatment and / or prevention of diabetes and its complications, senile dementia, Cardiovascular and cerebrovascular diseases, brain cell protection, central retinal vein occlusion, hyperlipidemia, fatty liver, and for preventing the recurrence of cardiovascular and cerebrovascular diseases and preventing restenosis after angioplasty. Background technique [0002] Diabetes is one of the four deadly diseases threatening human health. According to statistics, there are currently 130 million type II diabetes patients in the world, and 30 million in my country. There is currently no cure. The incidence of diabetes is getting higher and higher, and the age is getting younger. The quality of life of diabetic patients is seriously affected, which causes a significant economic and me...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K31/19A61K36/71A61K36/28A61P3/10A61P9/10A61P25/28
Inventor 林艳和潘锡平林谷风
Owner YUNNAN BIOVALLEY PHARMA CO LTD
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