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Pediatric paracetamol artifical low-bezoar and chlorphenzmine maleategel preparation and its preparing method

A technology of infantile paracetamol huangpheniramine gel and gel preparation, applied in anti-inflammatory agents, pharmaceutical formulations, non-central analgesics, etc., which can solve the problem of the application and report of pediatric paracetamol huangphenamine gel , Children are prone to resistance, affect the use effect and other problems, achieve great practical value and social and economic benefits, easy to swallow, good use effect

Inactive Publication Date: 2009-12-30
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing preparations of infantile paracetamol huangnaramine are mainly granules, although they are suitable for children, but because of their bitter taste and large amount, children are prone to resistance and affect the use effect
So far, there is no application and report of children's paracetamol huangnamin gel

Method used

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  • Pediatric paracetamol artifical low-bezoar and chlorphenzmine maleategel preparation and its preparing method
  • Pediatric paracetamol artifical low-bezoar and chlorphenzmine maleategel preparation and its preparing method
  • Pediatric paracetamol artifical low-bezoar and chlorphenzmine maleategel preparation and its preparing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] Party:

[0040] Acetaminophen 10g (1%)

[0041] Artificial bezoar 0.4g (0.04%)

[0042] Chlorpheniramine maleate 0.04g(0.004%)

[0043] Agar 4.6g (0.46%)

[0044] Sucrose 100g (10%)

[0045] Cyclodextrin 14.96g (1.496%)

[0046] Distilled water 870g (87%)

[0047] preparation:

[0048] According to the formula ratio, add cyclodextrin to distilled water at 95-100°C to make a saturated solution, slowly add acetaminophen, artificial bezoar and chlorpheniramine maleate, stir for 3 hours, and finally add the dissolved Sucrose and agar, filtered, cooled to room temperature, packed into sterilized containers, 5g per bag, sealed, and sterilized, to obtain the Pediatric Aminophen Huang Namin gel preparation.

Embodiment 2

[0050] Party:

[0051] Acetaminophen 200g (20%)

[0052] Artificial bezoar 0.8g (0.08%)

[0053] Chlorpheniramine Maleate 8g(0.80%)

[0054] Agar 2g (0.2%)

[0055] Sucrose 200g (20%)

[0056] Cyclodextrin 50g (5%)

[0057] Distilled water 539.2g (53.92%)

[0058] preparation:

[0059] According to the ratio of the formula, add cyclodextrin to distilled water at 80-85°C to make a saturated solution, slowly add acetaminophen, artificial bezoar and chlorpheniramine maleate, stir for 1.5 hours, and finally add the dissolved Sucrose and agar, filtered, cooled to room temperature, packed into sterilized containers, 10g per bag, sealed, and sterilized, to obtain the Pediatric Phytopheniramine Gel Preparation.

Embodiment 3

[0061] Party:

[0062] Acetaminophen 96g (9.6%)

[0063] Artificial bezoar 4g (0.4%)

[0064] Chlorpheniramine maleate 0.4g(0.04%)

[0065] Agar 100g (10%)

[0066] Sucrose 150g (15%)

[0067] Cyclodextrin 100g (10%)

[0068] Distilled water 549.6g (54.96%)

[0069] preparation:

[0070] According to the formula ratio, add cyclodextrin to 85-90°C distilled water to make a saturated solution, slowly add acetaminophen, artificial bezoar and chlorpheniramine maleate, stir for 1.5 hours, and finally add the dissolved Sucrose and agar, filtered, cooled to room temperature, packed into sterilized containers, 100mL per bottle, sealed, sterilized, to obtain the Pediatric Paracetamol Gel Preparation.

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Abstract

The present invention relates to a Xiaoer anfenhuangnamin gel preparation for children and its preparation method. Said gel preparation composition contains (by wt%) 0.05-30% of acetaminophen, 0.005-1% of artificial cow-bezoare, 0.0005-0.08% of chlorpheamine maleate, 0.2-10% of agar, 1-20% of cane sugar, 1-10% of cyclodextrin and 45-90% of water.

Description

(1) Technical field [0001] The invention relates to a gel preparation of infantile paracetamol and huangnamin and a preparation method thereof. (2) Background technology [0002] Pediatric paracetamol Huang Namin is a specific medicine for treating common cold in children. The acetaminophen in the prescription is an antipyretic and analgesic drug recommended by the World Health Organization. It has obvious antipyretic effect, less irritation to gastric mucosa, and does not cause gastric bleeding. Conventional doses have no obvious side effects, and are the first-selected antipyretics for children over 2 months old. They are used for fever caused by the common cold or influenza, and are also used to relieve mild to moderate pain; chlorpheniramine maleate has anti-allergic effects. It can relieve cough, nasal congestion, runny nose and other symptoms in colds; artificial bezoar can relieve colds, fever, sore throat, and irritability in children. [0003] The existing preparat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/00A61K35/413A61K31/4402A61K31/167A61P29/00A61P11/00
Inventor 王平苏为科张诚
Owner ZHEJIANG UNIV OF TECH