Sustained release preparation containing cilostazol and its preparation method
Patent Information
- Authority / Receiving Office
- CN ยท China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- SHENZHEN XINGYIN PHARML
- Publication Date
- 2007-08-15
Abstract
Description
technical field
[0001] The invention relates to the field of pharmaceutical preparations, in particular to a slow-release preparation containing cilostazol and a preparation method thereof. Background technique
[0002] The chemical name of cilostazol (cilostazol) is 6-[4-(1-cyclohexyl-1H-pentamethylene tetrazole (5')] butoxy-3,4-dihydro-1H quinolone (2'), and it is A new type of anti-platelet aggregation drug, by inhibiting the activity of phosphodiesterase in platelets and vascular smooth muscle, thereby increasing the concentration of cAMP in platelets and smooth muscle, exerting anti-platelet effect and vasodilator effect. This product inhibits ADP, epinephrine, collagen and peanut The platelet primary, secondary aggregation and release responses induced by tetraenoic acid are dose-related. The inhibition of platelet aggregation in vitro by oral administration of 100 mg cilostazol is 7-78 times stronger than that of the corresponding amount of aspirin (aspirin has no eff...