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Biological-degradable chitosan porous hemostasis material and its preparing method

A technology of biodegradable and hemostatic materials, applied in the field of chitosan porous hemostatic materials and its preparation, can solve the problems of adverse effects on the human body and non-degradable materials, and achieve the effects of enhanced hemostatic effect, large specific surface area, and enhanced water absorption performance

Inactive Publication Date: 2007-08-29
南京零一新材料工程研究中心(普通合伙) +1
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Problems solved by technology

However, this patent does not specifically relate to the materials for preparing such microporous particles, and the application of other types of porous materials as hemostatic materials in addition to microporous particles, such as porous fibers, porous sponges, etc., and the use of such porous hemostatic materials. The preparation method, and the material cannot be degraded, and may cause adverse effects on the human body

Method used

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  • Biological-degradable chitosan porous hemostasis material and its preparing method

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Embodiment Construction

[0027] 1. Preparation of Porous Chitosan Microspheres

[0028] 2g of chitosan with a degree of deacetylation of 90% and a viscosity average molecular weight of 500,000 was dissolved in 98g of 3% acetic acid aqueous solution, 5g of Tween 80 was added, and then 20g of vegetable soybean oil was added, vigorously stirred, and emulsified evenly. Add the above emulsion dropwise into 1000ml n-hexane containing 60g Span 85 which was stirred vigorously, emulsify for 1 hour, add 2ml, 20% glutaraldehyde aqueous solution, continue to stir for 1 hour, wash off the soybean oil with 50% ethanol aqueous solution after filtration and emulsifier, freeze-dried to obtain chitosan porous microspheres.

[0029] 2. Preparation of Chitosan Porous Fibers

[0030] 3g degree of deacetylation is 90%, chitosan with a viscosity-average molecular weight of 500,000 is dissolved in 97g, 5% acetic acid aqueous solution, 5g Triton x-100 and 10ml n-hexane are added, vigorously stirred and emulsified, and the ab...

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Abstract

The invention supplies a biodegradable nanometer channel multi orifice stanching material and manufacturing method which uses chitosan as raw material. It includes orifice making, forming, orifice making agent removing. The multi orifice structure can be gained by adding orifice making agent in preparation, removing it in forming, which emulsifies to form latex, solidifies to form hydrogel, removes the agent by alcohol or ketone solvent, dries the hydrogel, or processes cross linking for the formaldehyde, glutaraldehyde, solidifies chitosan aqueous solution to form hydrogel, removes the agent by water, dries the hydrogel. This material can fast adsorb the moisture in the blood to stanch.

Description

technical field [0001] The invention relates to a porous hemostatic material and a preparation method thereof, in particular to a biodegradable chitosan porous hemostatic material and a preparation method thereof. Background technique [0002] Hemostasis is an important part of first aid for various operations, war injuries, and trauma. The current hemostatic materials and hemostatic drugs are through embolization, contraction of small arteries and capillaries; enhancement of platelet function, acceleration and strengthening of blood coagulation process; inhibition of blood clot dissolution process; or Hemostasis is produced by burning, compressing, and suturing blood vessels. In the long-term production and living practice, people have found that materials with porous structure are often accompanied by good hemostatic function. For example, our ancestors used incense ash to stop bleeding very early, and residents in coastal areas often used cuttlefish bone powder to stop bl...

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Application Information

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IPC IPC(8): A61L15/28A61L31/06
Inventor 孙迪李锦韩民路新强
Owner 南京零一新材料工程研究中心(普通合伙)
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