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Linear light beam scanned surface plasma resonant imaging light intensity detection method and system

A surface plasmon and beam scanning technology, which is applied in measurement devices, scattering characteristic measurement, phase influence characteristic measurement, etc., can solve the problems of impossible high detection speed, low response frequency, and difficulty in meeting the requirements.

Inactive Publication Date: 2010-12-15
TSINGHUA UNIV
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Problems solved by technology

Obviously, there are three deficiencies in this system: one is that the accuracy mainly depends on the machining accuracy of related parts; the other is that the whole system is a mechanical motion system with motion damping, the response frequency is not high, and the detection speed cannot be high; the third is Mechanical movement is easy to cause micro vibration, which affects high-precision detection
However, biomedical research often needs to detect the interaction of several biomolecules at the same time, that is, multi-channel detection is required, and this invention is difficult to meet

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  • Linear light beam scanned surface plasma resonant imaging light intensity detection method and system
  • Linear light beam scanned surface plasma resonant imaging light intensity detection method and system
  • Linear light beam scanned surface plasma resonant imaging light intensity detection method and system

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Embodiment Construction

[0030] The light intensity detection method of linear beam scanning surface plasmon resonance imaging provided by the present invention, the specific detection steps are as follows:

[0031] 1) The light emitted by the laser is converged into a point beam, a linear beam or three beams of point light on the same straight line after passing through a group of optical elements, and then projected onto the vibrating mirror; the vibrating mirror is driven by a vibrating Driven to swing back and forth around a fixed axis; the set of optical elements can be composed of polarizers and lenses in turn to form point beams after convergence; or sequentially composed of polarizers and cylindrical mirrors to form linear beams after convergence Beams; or sequentially composed of polarizers, lenses and gratings, converged into three beams of point light on the same straight line.

[0032] 2) The point beam, linear light or three beams of point light on the same straight line that hit the vibr...

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Abstract

The linear light beam scanned surface plasma resonant imaging light intensity detection method and system belongs to the field of biological detection technology. In the incident optical path, one vibrating mirror driven with one vibration and oscillation driver is set to alter the incident angle to the sensing surface and to complete linear light beam scanning. When the biomolecules in the surface of the protein chip act mutually, the vibration mirror reflected light radiates to the sensing surface in constantly changed angle to excite the surface plasma on the protein chip to resonate constantly, so as to obtain corresponding light intensity signal with the photoelectronic detector. Once the vibration mirror frequency is fixed, the detector signal is recorded to complete the detection. The present invention has simple system structure, high sensitivity, high precision and capacity of multichannel detection.

Description

technical field [0001] The invention belongs to the technical field of biological detection, and particularly relates to a detection method and a biochip detection system for realizing high-precision, real-time sensing of protein-protein, protein-DNA, protein-effector, antigen-antibody and other biomolecular interactions. Background technique [0002] The essence of surface plasmon resonance imaging sensing is to sense the refractive index change of the detected surface. The interface between the glass substrate and the gold film of the sensor chip is the sensing surface. When the biomolecules in the sample interact with the biomolecules immobilized on the sensing surface, the structure of the sensing surface will change, that is, the refractive index change. Accordingly, the incident angle of the light that excites the surface plasmon resonance needs to be changed accordingly. When surface plasmon resonance occurs, the intensity of the corresponding reflected light will i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/41G01N21/55G01N21/552
CPCG01N21/553
Inventor 余兴龙章恩耀闫硕
Owner TSINGHUA UNIV
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