Composition of amino acid

A technology of threonine and leucine, which can be used in drug combinations, dipeptide components, metabolic diseases, etc., and can solve problems such as poor efficacy and incomplete composition of amino acid injections.

Active Publication Date: 2007-10-10
BEIJING SHIQIAO BIOPHAM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the composition of commercially available amino acid injections that can be applied clinically has not been perfected so far, and the efficacy is poor in the treatment of critically ill patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Under nitrogen protection, aspartic acid 4.00g, threonine 4.32g, serine 5.00g, glutamic acid 1.60g, proline 5.00g, glycine 3.20g, alanine 0.60g, N(2)-L- Alanyl-L-glutamine 18.05g, valine 9.50g, methionine 3.20g, isoleucine 7.50g, leucine 13.00g, phenylalanine 3.75g, lysine acetate 7.05 g, histidine 2.60g, arginine 8.60g, acetylcysteine ​​1.01g, acetyltyrosine 0.92g, tryptophan 1.08g, taurine 1.00g, sodium bisulfite 0.5g in water for injection Dissolve in 1000ml and make up to 1000ml, filter, fill in 250ml infusion bottle, stopper and cover, heat sterilize, cool to get injection.

[0027] A variety of drug efficacy tests conducted by the inventors show that the present invention has a good nutritional support effect, and is superior to existing technical solutions in many aspects. With embodiment 1 and comparative example 1 injection through total intravenous nutrition administration to short bowel syndrome rat test, in reflecting some indexes of body immune function (t...

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PUM

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Abstract

An amino acid composition with high nutrition supporting effect is composed of acetylcysteine, acetyltyrosine and tryptophan in weight ratio of (0.81-2): (0.81-2): (0.9-1.6).

Description

technical field [0001] The present invention relates to an amino acid composition. Background technique [0002] The progress of modern science and technology can make many diseases get satisfactory treatment, but the malnutrition of clinical patients still exists, accounting for about 50% of the inpatients, and the main manifestation is protein energy malnutrition. [0003] Protein is the main component of all living cells and body fluids, and is the material basis for maintaining the growth, development, and tissue repair and renewal of the body. Amino acids are the basic units that make up proteins. There are 20 kinds of amino acids that normally make up proteins in the human body. These include 8 essential amino acids and 12 non-essential amino acids, the former including: isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, valine , the body cannot synthesize or the synthesis rate cannot meet the needs, and must be supplied by food; the latte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/05A61P3/02A61P37/04A61K31/4172A61K31/405A61K31/198
Inventor 陈定刘烽林韶辉
Owner BEIJING SHIQIAO BIOPHAM
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