Production and use for algin oligose

A technology of alginate oligosaccharide and alginate, applied in the directions of oligosaccharides, fungi, etc., can solve the problems of chemical substance residue, high cost, difficult control of process conditions, etc., and achieves low cost, less equipment, and analgesic effect. Effect

Inactive Publication Date: 2007-11-21
威海长青海洋科技股份有限公司
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AI Technical Summary

Problems solved by technology

[0004] In order to overcome the deficiencies in the prior art that the process conditions are not easy to control, the cost is high, and the residue of chemical substances, etc., t...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Algin oligosaccharides are prepared according to the following method: Take 5.0 g of algin solid with a viscosity average molecular weight of 128,000, and use 2.5% acetic acid solution to prepare 400 mL of 1.25% algin solution. When the temperature is 60 ° C and the pH value is 4.0 When the value is high, use 150 Hz ultrasonic wave under the condition of 80% power to carry out ultrasonic degradation for 8 hours, add absolute ethanol to the degradation solution for alcohol analysis, filter with suction, dry, and grind to obtain 4.6 g of alginate oligosaccharides. Its average degree of polymerization is 8.

Embodiment 2

[0018] Alginate oligosaccharides are prepared according to the following method: Take 12.0 g of alginate solids with a viscosity-average molecular weight of 128,000, and use 2.5% acetic acid solution to prepare 400 mL of 3.0% alginate solution. When the temperature is 80 ° C and the pH value is 3.0 10.5 g of algin oligosaccharides was obtained by adding anhydrous ethanol to the degradation solution for alcohol analysis, suction filtration, drying, and grinding. Its average degree of polymerization was 10.

[0019] The following is a detailed description of the experimental method and experimental results that algin oligosaccharides can be used as natural antibacterial agents with high antibacterial activity.

[0020] The screening and effect evaluation methods of the prepared alginate oligosaccharide antibacterial test are as follows:

[0021] Using 2.5% alginate, 2.5% sodium benzoate and normal saline as controls, the antibacterial effect of 2.5% alginate oligosaccharide sol...

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Abstract

Production of algin oligose and its usage are disclosed. The process is carried out by degrading for 1-5% algin solution at 40-80 degree and pH value 2-5 by supersonic wave for 7-10 hrs, adding anhydrous alcohol into degrading liquid, eluting by alcohol, extraction filtering, drying and grinding to obtain final product. The average polymerization is below 10 degree. It's simple and cheap, it can inhibit Gram-negative bacterium or positive bacterium growth effectively, have better broad-spectrum antibacterial activity, anti-inflammatory and analgetic functions.

Description

technical field [0001] The invention relates to the preparation and application of sugars, in particular to a method for preparing algin oligosaccharides as a bacteriostatic agent by using algin as a raw material. Background technique [0002] Glycopolymers with a degree of polymerization between 2 and 20 are defined as oligosaccharides. Compared with alginate polymers, oligosaccharides have the advantages of strong solubility, good stability, and easy absorption by the body. In recent years, many experts and scholars have conducted research on the preparation of algin oligosaccharides. For example, the "manufacturing method of algin oligosaccharides" disclosed in the Chinese invention patent specification CN1161368C announced on August 11, 2004, the method adopts What is more important is that the acid hydrolysis of alginate in the presence of an oxidizing agent needs to be carried out in a strong acid environment, and the technical conditions are not easy to control; the C...

Claims

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Application Information

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IPC IPC(8): C07H3/06C08B37/04C12N1/18
Inventor 张淑平胡佩红卞永平李长青
Owner 威海长青海洋科技股份有限公司
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