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Traditional Chinese medicine freeze dried injection for curing cerebral infarction and preparation method thereof

A technology of freeze-dried powder injection and cerebral infarction, which is applied in the field of traditional Chinese medicine freeze-dried powder injection and its preparation for the treatment of cerebral infarction, and can solve problems such as opalescence, unqualified clarity of the preparation, and unstable quality.

Active Publication Date: 2007-12-12
HENAN NEW CENTURY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this product is mainly a solution-type injection containing volatile oil. Due to the slight supersaturation of the volatile oil in the aqueous solution, or the oxidation of the volatile oil due to the influence of external conditions (such as light and air), opalescence occurs, resulting in the clarity of the preparation. Unqualified, unstable quality; in addition, the original prescription mainly uses musk to rejuvenate the mind, and gardenia mainly relieves pericardial fire, clears away heat and detoxifies, and helps musk to penetrate the envelope. This has a certain dose-effect relationship with its main active ingredient, geniposide. However, no research has been done on this

Method used

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  • Traditional Chinese medicine freeze dried injection for curing cerebral infarction and preparation method thereof
  • Traditional Chinese medicine freeze dried injection for curing cerebral infarction and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0214] Embodiment 1: Preparation of freeze-dried powder injection

[0215] a. Take the following raw drug components in parts by weight: musk 15g, turmeric 60g, gardenia 60g, borneol 1g;

[0216] b. For the above four flavors, the turmeric is crushed into coarse particles, and the volatile oil is extracted for later use; the Gardenia jasminoides is extracted with ethanol, filtered, and the extracts are combined, the ethanol is recovered, concentrated into an extract, and the pH of the extract is adjusted with HCl, boiled, cooled, Centrifuge after refrigeration, extract the centrifugate with n-butanol, combine the n-butanol extracts, recover n-butanol under reduced pressure, concentrate, and dry to obtain the gardenia extract; musk is extracted with ethanol continuous reflux, and the extract is used for later use; borneol is crushed for later use; According to the preparation method of freeze-dried powder injection, the above-mentioned substances are prepared into freeze-dried ...

Embodiment 2

[0217] Embodiment 2: Preparation of freeze-dried powder injection

[0218] a. Take the following raw material drug components in parts by weight: musk 90g, turmeric 300g, gardenia 300g, borneol 6g;

[0219] b. For the above four flavors, the turmeric is crushed into coarse particles, and the volatile oil is extracted for later use; the Gardenia jasminoides is extracted with ethanol, filtered, and the extracts are combined, the ethanol is recovered, concentrated into an extract, and the pH of the extract is adjusted with HCl, boiled, cooled, Centrifuge after refrigeration, extract the centrifugate with n-butanol, combine the n-butanol extracts, recover n-butanol under reduced pressure, concentrate, and dry to obtain the gardenia extract; musk is extracted with ethanol continuous reflux, and the extract is used for later use; borneol is crushed for later use;

[0220] Take hydroxypropyl-β-cyclodextrin, add water to dissolve, take the turmeric volatile oil and add it dropwise int...

Embodiment 3

[0221] Embodiment 3: Preparation of freeze-dried powder injection

[0222] a. Take musk 37.5g, turmeric 150g, gardenia 150g, borneol 5g;

[0223] b. The above four flavors and turmeric are crushed into coarse particles, and the volatile oil is extracted for later use; Gardenia is extracted 5 times with 14 times the amount of 99.5% ethanol under reflux, each time for 1 hour, filtered, combined extracts, the filtrate is decompressed to recover ethanol, and When concentrated to 50°C, the relative density is about 1.10 to 1.25. The extract is adjusted to a pH of 1 to 4 with HCl, boiled for 3 hours, cooled, refrigerated for 36 hours, centrifuged, and the centrifuged liquid is extracted 8 times with n-butanol. Combine n-butanol extracts, recover n-butanol under reduced pressure, concentrate to an extract with a relative density of about 1.10-1.35 (50°C), and dry to obtain Gardenia jasmine extract; musk is extracted with 8 times the amount of 99.5% ethanol under reflux 6 hour, the e...

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Abstract

The invention relates to a Chinese medicinal freeze dried powder for treating acute brain infarction and process for preparation, wherein the medicament is prepared from musk, curcuma aromatica, cape jasmine and borneol through dressing the raw material herbs, making medicinal preparation and carrying out detection, and controlling the content of active constituents in the freeze-dried powder injection. The medicament of the invention has the effects of heat-clearing, purging the pathogenic fire, removing heat from blood and detoxification.

Description

technical field [0001] The invention relates to a medical preparation for treating cerebral infarction, more specifically, a traditional Chinese medicine freeze-dried powder injection for treating cerebral infarction made from traditional Chinese medicine and a preparation method thereof. Background technique [0002] Cerebral infarction, also known as ischemic cerebrovascular disease, is a disease caused by insufficient blood supply to the brain due to thrombus, embolism or other reasons in the cerebral blood vessels. Cerebral infarction includes common cerebral arteriosclerosis thrombotic cerebral infarction (referred to as cerebral thrombosis) and cerebral embolism. In addition, there is transient ischemic attack, also known as transient cerebral ischemia, which also belongs to the category of ischemic cerebrovascular disease, but it has not reached the point of cerebral infarction. Chinese medicine refers to such diseases as stroke, but stroke also includes cerebral hem...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/19A61P9/10A61P7/02A61K35/55A61K31/045
Inventor 叶正良李永强郑永锋李瑞明
Owner HENAN NEW CENTURY PHARMA
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